SF3B2 (splicing factor 3b subunit 2)

2016-03-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
Cus1,SAP145,SF3B145,SF3b1,SF3b150
FUSION GENES

Other Information

Locus ID:

NCBI: 10992
MIM: 605591
HGNC: 10769
Ensembl: ENSG00000087365

Variants:

dbSNP: 10992
ClinVar: 10992
TCGA: ENSG00000087365
COSMIC: SF3B2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087365ENST00000322535Q13435
ENSG00000087365ENST00000524475E9PIL8
ENSG00000087365ENST00000524627E9PJT3
ENSG00000087365ENST00000528302E9PPJ0
ENSG00000087365ENST00000530322H0YCG1
ENSG00000087365ENST00000530981H0YEX5
ENSG00000087365ENST00000533595E9PJ04

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U2-snRNPKEGGhsa_M00352
Spliceosome, U2-snRNPKEGGM00352
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA Splicing - Minor PathwayREACTOMER-HSA-72165

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
332906322021G-quadruplex-forming nucleic acids interact with splicing factor 3B subunit 2 and suppress innate immune gene expression.8
343448872021Haploinsufficiency of SF3B2 causes craniofacial microsomia.22
332906322021G-quadruplex-forming nucleic acids interact with splicing factor 3B subunit 2 and suppress innate immune gene expression.8
343448872021Haploinsufficiency of SF3B2 causes craniofacial microsomia.22
314314562019SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression.39
314314562019SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression.39
297051352018Multiple roles of the splicing complex SF3B in DNA end resection and homologous recombination.14
297051352018Multiple roles of the splicing complex SF3B in DNA end resection and homologous recombination.14
278625522017Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment.3
278625522017Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment.3
257316162015Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC).40
259793442015Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.54
257316162015Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC).40
259793442015Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.54
224157772012Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry.9

Citation

Dessen P

SF3B2 (splicing factor 3b subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-03-01

Online version: http://atlasgeneticsoncology.org/gene/55690/sf3b2-(splicing-factor-3b-subunit-2)