CRBN (cereblon)

2016-03-01  

Identity

HGNC
LOCATION
3p26.2
LOCUSID
ALIAS
MRT2,MRT2A
FUSION GENES

Other Information

Locus ID:

NCBI: 51185
MIM: 609262
HGNC: 30185
Ensembl: ENSG00000113851

Variants:

dbSNP: 51185
ClinVar: 51185
TCGA: ENSG00000113851
COSMIC: CRBN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113851ENST00000231948Q96SW2
ENSG00000113851ENST00000231948A0A024R2H8
ENSG00000113851ENST00000424814J3QT87
ENSG00000113851ENST00000432408Q96SW2
ENSG00000113851ENST00000450014J3QT51
ENSG00000113851ENST00000629101A0A0D9SF49
ENSG00000113851ENST00000639284A0A1W2PPJ5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
250430122014Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.174
218600262011Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.173
226983992012Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma.138
243286782014Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).121
251083552014Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.95
155575132004A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation.65
274580042016Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes.40
232336572013High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance.39
269909862016Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.37
261199392016Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors.34

Citation

Dessen P

CRBN (cereblon)

Atlas Genet Cytogenet Oncol Haematol. 2016-03-01

Online version: http://atlasgeneticsoncology.org/gene/55691/crbn-(cereblon)