CNOT9 (CCR4-NOT transcription complex subunit 9)

2016-04-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
CAF40,CT129,RCD-1,RCD1,RQCD1

Other Information

Locus ID:

NCBI: 9125
MIM: 612054
HGNC: 10445
Ensembl: ENSG00000144580

Variants:

dbSNP: 9125
ClinVar: 9125
TCGA: ENSG00000144580
COSMIC: CNOT9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144580ENST00000273064Q92600
ENSG00000144580ENST00000273064D5MQE1
ENSG00000144580ENST00000295701Q92600
ENSG00000144580ENST00000418808H7C0W0
ENSG00000144580ENST00000432877F8WBZ6
ENSG00000144580ENST00000433439F8WCV7
ENSG00000144580ENST00000542068Q92600
ENSG00000144580ENST00000542068D5MQE1
ENSG00000144580ENST00000627282Q92600

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370925382023De novo variants in CNOT9 cause a neurodevelopmental disorder with or without epilepsy.0
370925382023De novo variants in CNOT9 cause a neurodevelopmental disorder with or without epilepsy.0
299249582019Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway.16
299249582019Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway.16
292913912018Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.26
303098862018The central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4-Not nuclease module.12
292913912018Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.26
303098862018The central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4-Not nuclease module.12
255447602015Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma.17
255447602015Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma.17
247685382014Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.167
247685402014A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.153
247685382014Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.167
247685402014A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.153
208780562010Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.8

Citation

Dessen P

CNOT9 (CCR4-NOT transcription complex subunit 9)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55699/cnot9-(ccr4-not-transcription-complex-subunit-9)