MRM2 (mitochondrial rRNA methyltransferase 2)

2016-04-01  

Identity

HGNC
LOCATION
7p22.3
LOCUSID
ALIAS
FJH1,FTSJ2,HEL97,MTDPS17,RRMJ2

Other Information

Locus ID:

NCBI: 29960
MIM: 606906
HGNC: 16352
Ensembl: ENSG00000122687

Variants:

dbSNP: 29960
ClinVar: 29960
TCGA: ENSG00000122687
COSMIC: MRM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122687ENST00000242257Q9UI43
ENSG00000122687ENST00000242257V9HWJ9
ENSG00000122687ENST00000440306Q9UI43
ENSG00000122687ENST00000440306V9HWJ9
ENSG00000122687ENST00000486040A0A3B3ITW8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
rRNA processing in the mitochondrionREACTOMER-HSA-8868766
rRNA modification in the mitochondrionREACTOMER-HSA-6793080

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
360022402023MRM2 variants in families with complex dystonic syndromes: evidence for phenotypic heterogeneity.1
360022402023MRM2 variants in families with complex dystonic syndromes: evidence for phenotypic heterogeneity.1
288661012017MiR-542-3p exerts tumor suppressive functions in non-small cell lung cancer cells by upregulating FTSJ2.13
289731712017Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome.40
288661012017MiR-542-3p exerts tumor suppressive functions in non-small cell lung cancer cells by upregulating FTSJ2.13
289731712017Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome.40
245950622014FTSJ2, a heat shock-inducible mitochondrial protein, suppresses cell invasion and migration.6
250092822014MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome.68
250749362014Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA).49
245950622014FTSJ2, a heat shock-inducible mitochondrial protein, suppresses cell invasion and migration.6
250092822014MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome.68
250749362014Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA).49
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
118274512002Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase.12

Citation

Dessen P

MRM2 (mitochondrial rRNA methyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55708/mrm2-(mitochondrial-rrna-methyltransferase-2)