TOLLIP (toll interacting protein)

2016-04-01  

Identity

HGNC
TOLLIP
LOCATION
11p15.5
LOCUSID
54472
ALIAS
IL-1RAcPIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54472
MIM: 606277
HGNC: 16476
Ensembl: ENSG00000078902

Variants:

dbSNP: 54472
ClinVar: 54472
TCGA: ENSG00000078902
COSMIC: TOLLIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078902ENST00000263646E7EN89
ENSG00000078902ENST00000317204Q9H0E2
ENSG00000078902ENST00000317204Q6FIE9
ENSG00000078902ENST00000525159F2Z2Y8
ENSG00000078902ENST00000527886Q9H0E2
ENSG00000078902ENST00000527938E9PNS3
ENSG00000078902ENST00000530506E9PP67
ENSG00000078902ENST00000530541E9PQ25

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445468Pulmonary FibrosisDiseaseClinicalAnnotationassociatedPD
PA448033acetylcysteineChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
376443702023Toll-interacting protein may affect doxorubicin resistance in hepatocellular carcinoma cell lines.0
381247532023Tollip deficiency exaggerates airway type 2 inflammation in mice exposed to allergen and influenza A virus: role of the ATP/IL-33 signaling axis.1
376443702023Toll-interacting protein may affect doxorubicin resistance in hepatocellular carcinoma cell lines.0
381247532023Tollip deficiency exaggerates airway type 2 inflammation in mice exposed to allergen and influenza A virus: role of the ATP/IL-33 signaling axis.1
344194272022Alternative Gene Expression by TOLLIP Variant Is Associated With Lung Function in Chronic Hypersensitivity Pneumonitis.2
351646502022Somatostatin attenuates intestinal epithelial barrier injury during acute intestinal ischemia-reperfusion through Tollip/Myeloiddifferentiationfactor 88/Nuclear factor kappa-B signaling.1
358036952022TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.4
364990302022TOLLIP Protein Expression Predicts Unfavorable Outcome in Renal Cell Carcinoma.1
344194272022Alternative Gene Expression by TOLLIP Variant Is Associated With Lung Function in Chronic Hypersensitivity Pneumonitis.2
351646502022Somatostatin attenuates intestinal epithelial barrier injury during acute intestinal ischemia-reperfusion through Tollip/Myeloiddifferentiationfactor 88/Nuclear factor kappa-B signaling.1
358036952022TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.4
364990302022TOLLIP Protein Expression Predicts Unfavorable Outcome in Renal Cell Carcinoma.1
331285792021Toll-interacting protein impacts on inflammation, autophagy, and vacuole trafficking in human disease.11
332339202021Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle.7
336399952021Potential clinical utility of MUC5B und TOLLIP single nucleotide polymorphisms (SNPs) in the management of patients with IPF.20

Citation

Dessen P

TOLLIP (toll interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55714/img/gene-fusions/welcome