FADS1 (fatty acid desaturase 1)

2016-04-01  

Identity

HGNC
LOCATION
11q12.2
LOCUSID
ALIAS
D5D,FADS6,FADSD5,LLCDL1,TU12
FUSION GENES

Other Information

Locus ID:

NCBI: 3992
MIM: 606148
HGNC: 3574
Ensembl: ENSG00000149485

Variants:

dbSNP: 3992
ClinVar: 3992
TCGA: ENSG00000149485
COSMIC: FADS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149485ENST00000350997A0A0A0MR51
ENSG00000149485ENST00000421879C9JJB3
ENSG00000149485ENST00000424501H7C2V0
ENSG00000149485ENST00000433932O60427
ENSG00000149485ENST00000448607C9J425
ENSG00000149485ENST00000460649F5H3P6
ENSG00000149485ENST00000466716F5H2H3
ENSG00000149485ENST00000473263F5H2R9
ENSG00000149485ENST00000491310H0YB97
ENSG00000149485ENST00000536991F5H3U5
ENSG00000149485ENST00000539419F5H1Q7
ENSG00000149485ENST00000539999F5H8G5
ENSG00000149485ENST00000540767F5GWE3
ENSG00000149485ENST00000542506O60427
ENSG00000149485ENST00000544309F5H0Y2
ENSG00000149485ENST00000544696F5H5X5
ENSG00000149485ENST00000545245F5H852
ENSG00000149485ENST00000545405F5GYH4

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Biosynthesis of unsaturated fatty acidsKEGGko01040
Biosynthesis of unsaturated fatty acidsKEGGhsa01040
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
alpha-linolenic (omega3) and linoleic (omega6) acid metabolismREACTOMER-HSA-2046104
alpha-linolenic acid (ALA) metabolismREACTOMER-HSA-2046106
Linoleic acid (LA) metabolismREACTOMER-HSA-2046105

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
377287462024Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men.0
383167672024Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function.0
385665502024Impact of FADS genotype on polyunsaturated fatty acid content in human milk extracellular vesicles: A genetic association study.0
377287462024Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men.0
383167672024Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function.0
385665502024Impact of FADS genotype on polyunsaturated fatty acid content in human milk extracellular vesicles: A genetic association study.0
366525412023Placental expression of Fatty Acid Desaturases 1, 2 and 3 in selected pregnancy pathologies.1
367714292023Association of Fatty Acid Desaturase 1 rs174547 Polymorphism with the Composition of Long-Chain Polyunsaturated Fatty Acids in Serum Glycerophospholipids during Pregnancy.0
368064962023Effect of FADS1 rs174556 Genotype on Polyunsaturated Fatty Acid Status: A Systematic Review and Meta-Analysis.0
368641352023Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.10
370411602023FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer.6
366525412023Placental expression of Fatty Acid Desaturases 1, 2 and 3 in selected pregnancy pathologies.1
367714292023Association of Fatty Acid Desaturase 1 rs174547 Polymorphism with the Composition of Long-Chain Polyunsaturated Fatty Acids in Serum Glycerophospholipids during Pregnancy.0
368064962023Effect of FADS1 rs174556 Genotype on Polyunsaturated Fatty Acid Status: A Systematic Review and Meta-Analysis.0
368641352023Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.10

Citation

Dessen P

FADS1 (fatty acid desaturase 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55715/fads1-(fatty-acid-desaturase-1)