Identity
HGNC
LOCATION
2p22.3
LOCUSID
ALIAS
Cps25,HDPY-30,Saf19
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84661
MIM: 612032
HGNC: 24590
Ensembl: ENSG00000162961
Variants:
dbSNP: 84661
ClinVar: 84661
TCGA: ENSG00000162961
COSMIC: DPY30
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000162961 | ENST00000295066 | Q9C005 |
| ENSG00000162961 | ENST00000342166 | Q9C005 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| PKMTs methylate histone lysines | REACTOME | R-HSA-3214841 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37324189 | 2023 | DPY30 Promotes Proliferation and Cell Cycle Progression of Colorectal Cancer Cells via Mediating H3K4 Trimethylation. | 3 |
| 37324189 | 2023 | DPY30 Promotes Proliferation and Cell Cycle Progression of Colorectal Cancer Cells via Mediating H3K4 Trimethylation. | 3 |
| 34985972 | 2022 | Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases. | 13 |
| 34985972 | 2022 | Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases. | 13 |
| 34012049 | 2021 | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. | 13 |
| 34012049 | 2021 | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. | 13 |
| 31065682 | 2020 | A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells. | 11 |
| 31065682 | 2020 | A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells. | 11 |
| 29288530 | 2018 | PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein. | 8 |
| 29481671 | 2018 | Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia. | 15 |
| 30221689 | 2018 | DPY30 is required for the enhanced proliferation, motility and epithelial-mesenchymal transition of epithelial ovarian cancer cells. | 14 |
| 30448059 | 2018 | DPY30 functions in glucose homeostasis via integrating activated histone epigenetic modifications. | 3 |
| 29288530 | 2018 | PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein. | 8 |
| 29481671 | 2018 | Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia. | 15 |
| 30221689 | 2018 | DPY30 is required for the enhanced proliferation, motility and epithelial-mesenchymal transition of epithelial ovarian cancer cells. | 14 |
Citation
Dessen P
DPY30 (dpy-30 histone methyltransferase complex regulatory subunit)
Atlas Genet Cytogenet Oncol Haematol. 2016-04-01
Online version: http://atlasgeneticsoncology.org/gene/55728/dpy30-(dpy-30-histone-methyltransferase-complex-regulatory-subunit)
