DPY30 (dpy-30 histone methyltransferase complex regulatory subunit)

2016-04-01  

Identity

HGNC
DPY30
LOCATION
2p22.3
LOCUSID
84661
ALIAS
Cps25,HDPY-30,Saf19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84661
MIM: 612032
HGNC: 24590
Ensembl: ENSG00000162961

Variants:

dbSNP: 84661
ClinVar: 84661
TCGA: ENSG00000162961
COSMIC: DPY30

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162961ENST00000295066Q9C005
ENSG00000162961ENST00000342166Q9C005

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
spleen
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
175000652007PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.252
255617382015Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.27
222316282012Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.19
251393542014The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.19
194810962009Crystal structure of the C-terminal domain of human DPY-30-like protein: A component of the histone methyltransferase complex.18
238729462013DPY30 regulates pathways in cellular senescence through ID protein expression.14
266915082015Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.10
261473372015Roles of DPY30 in the Proliferation and Motility of Gastric Cancer Cells.7
208573102011Partial SPAST and DPY30 deletions in a Japanese spastic paraplegia type 4 family.4
255422092015Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation.4

Citation

Dessen P

DPY30 (dpy-30 histone methyltransferase complex regulatory subunit)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55728/dpy30-(dpy-30-histone-methyltransferase-complex-regulatory-subunit)