RCE1 (Ras converting CAAX endopeptidase 1)

2016-04-01  

Identity

HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
FACE2,RCE1A,RCE1B

Other Information

Locus ID:

NCBI: 9986
MIM: 605385
HGNC: 13721
Ensembl: ENSG00000173653

Variants:

dbSNP: 9986
ClinVar: 9986
TCGA: ENSG00000173653
COSMIC: RCE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173653ENST00000309657Q9Y256
ENSG00000173653ENST00000524506E9PI08
ENSG00000173653ENST00000524849E9PPV9
ENSG00000173653ENST00000525356E9PKA7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Terpenoid backbone biosynthesisKEGGko00900
Terpenoid backbone biosynthesisKEGGhsa00900
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
315069522020Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial-mesenchymal transition induced by the TGF-β1/H-Ras signaling pathway.6
315069522020Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial-mesenchymal transition induced by the TGF-β1/H-Ras signaling pathway.6
281599792017Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress.3
286150752017Reduced RCE1 expression predicts poor prognosis of colorectal carcinoma.2
281599792017Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress.3
286150752017Reduced RCE1 expression predicts poor prognosis of colorectal carcinoma.2
265462522016Overexpressed Rce1 is positively correlated with tumor progression and predicts poor prognosis in prostate cancer.5
265462522016Overexpressed Rce1 is positively correlated with tumor progression and predicts poor prognosis in prostate cancer.5
241343112014A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17.10
241343112014A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17.10
163617102006Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.32
163617102006Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.32
128181872003Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides.5
145042652003A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation.32
128181872003Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides.5

Citation

Dessen P

RCE1 (Ras converting CAAX endopeptidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55737/rce1-(ras-converting-caax-endopeptidase-1)