FBXO7 (F-box protein 7)

2016-05-01  

Identity

HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
FBX,FBX07,FBX7,PARK15,PKPS
FUSION GENES

Other Information

Locus ID:

NCBI: 25793
MIM: 605648
HGNC: 13586
Ensembl: ENSG00000100225

Variants:

dbSNP: 25793
ClinVar: 25793
TCGA: ENSG00000100225
COSMIC: FBXO7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100225ENST00000266087Q9Y3I1
ENSG00000100225ENST00000397426Q9Y3I1
ENSG00000100225ENST00000420700F8WBR0
ENSG00000100225ENST00000425028F8WDR9
ENSG00000100225ENST00000444207A2A282
ENSG00000100225ENST00000452138Q9Y3I1

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
388397522024FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma.0
388397522024FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma.0
362610862023The characteristics of FBXO7 and its role in human diseases.5
373444802023FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division.3
378221602023FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.4
378748272023USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7.2
362610862023The characteristics of FBXO7 and its role in human diseases.5
373444802023FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division.3
378221602023FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.4
378748272023USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7.2
347912502022The F-box protein, FBXO7, is required to maintain chromosome stability in humans.5
356707642022Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.3
362743282022Novel bi-allelic FBXO7 variants in a family with early-onset typical Parkinson's disease.1
347912502022The F-box protein, FBXO7, is required to maintain chromosome stability in humans.5
356707642022Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.3

Citation

Dessen P

FBXO7 (F-box protein 7)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55738/fbxo7-(f-box-protein-7)