ZSCAN4 (zinc finger and SCAN domain containing 4)

2016-05-01  

Identity

HGNC
ZSCAN4
LOCATION
19q13.43
LOCUSID
201516
ALIAS
ZNF494
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 201516
MIM: 613419
HGNC: 23709
Ensembl: ENSG00000180532

Variants:

dbSNP: 201516
ClinVar: 201516
TCGA: ENSG00000180532
COSMIC: ZSCAN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180532ENST00000318203Q8NAM6
ENSG00000180532ENST00000612521Q8NAM6

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
381537672024ZSCAN4-binding motif-TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes.1
381537672024ZSCAN4-binding motif-TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes.1
368417762023Low expression of ZSCAN4 predicts unfavorable outcome in urothelial carcinoma of upper urinary tract and urinary bladder.1
368417762023Low expression of ZSCAN4 predicts unfavorable outcome in urothelial carcinoma of upper urinary tract and urinary bladder.1
325078612020ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype.16
326682442020The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming.16
325078612020ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype.16
326682442020The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming.16
294778412018ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20.9
297129042018The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.64
294778412018ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20.9
297129042018The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.64
276996512017Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos.7
276996532017Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis.8
276996512017Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos.7

Citation

Dessen P

ZSCAN4 (zinc finger and SCAN domain containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55746/zscan4-(zinc-finger-and-scan-domain-containing-4)