TBL1X (transducin beta like 1 X-linked)

2016-05-01  

Identity

HGNC
LOCATION
Xp22.31
LOCUSID
ALIAS
CHNG8,EBI,SMAP55,TBL1
FUSION GENES

Other Information

Locus ID:

NCBI: 6907
MIM: 300196
HGNC: 11585
Ensembl: ENSG00000101849

Variants:

dbSNP: 6907
ClinVar: 6907
TCGA: ENSG00000101849
COSMIC: TBL1X

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101849ENST00000380961O60907
ENSG00000101849ENST00000407597O60907
ENSG00000101849ENST00000407597A0A024RBV9
ENSG00000101849ENST00000415293C9JYQ8
ENSG00000101849ENST00000422314C9JCW3
ENSG00000101849ENST00000424279O60907
ENSG00000101849ENST00000441088C9JP56
ENSG00000101849ENST00000452824C9J5F9
ENSG00000101849ENST00000645353O60907
ENSG00000101849ENST00000645353A0A024RBV9
ENSG00000101849ENST00000645686O60907
ENSG00000101849ENST00000645686A0A024RBV9
ENSG00000101849ENST00000646640O60907
ENSG00000101849ENST00000646640A0A024RBV9
ENSG00000101849ENST00000647060A0A2R8YFW3
ENSG00000101849ENST00000647172A0A2R8Y757

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
368601952023Further Delineation of Central Congenital Hypothyroidism due to Variants in TBL1X and IRS4.0
373564582023Long noncoding RNA MIAT regulates TP53 ubiquitination and expedites prostate adenocarcinoma progression by recruiting TBL1X.2
368601952023Further Delineation of Central Congenital Hypothyroidism due to Variants in TBL1X and IRS4.0
373564582023Long noncoding RNA MIAT regulates TP53 ubiquitination and expedites prostate adenocarcinoma progression by recruiting TBL1X.2
362068732022TBL1X: At the crossroads of transcriptional and posttranscriptional regulation.4
362068732022TBL1X: At the crossroads of transcriptional and posttranscriptional regulation.4
330541362021Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma.3
330541362021Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma.3
301608332018Ocular albinism with infertility and late-onset sensorineural hearing loss.4
304630812018Integrated Transcriptome Sequencing Analysis Reveals Role of miR-138-5p/ TBL1X in Placenta from Gestational Diabetes Mellitus.25
301608332018Ocular albinism with infertility and late-onset sensorineural hearing loss.4
304630812018Integrated Transcriptome Sequencing Analysis Reveals Role of miR-138-5p/ TBL1X in Placenta from Gestational Diabetes Mellitus.25
283482412017Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.42
283482412017Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.42
271291642016SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth.8

Citation

Dessen P

TBL1X (transducin beta like 1 X-linked)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55748/tbl1x-(transducin-beta-like-1-x-linked)