NLGN3 (neuroligin 3)

2016-05-01  

Identity

HGNC
LOCATION
Xq13.1
LOCUSID
ALIAS
HNL3
FUSION GENES

Other Information

Locus ID:

NCBI: 54413
MIM: 300336
HGNC: 14289
Ensembl: ENSG00000196338

Variants:

dbSNP: 54413
ClinVar: 54413
TCGA: ENSG00000196338
COSMIC: NLGN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196338ENST00000358741Q9NZ94
ENSG00000196338ENST00000358741X5DNV3
ENSG00000196338ENST00000374051Q9NZ94
ENSG00000196338ENST00000374051X5D2P6
ENSG00000196338ENST00000395855E7EVK0
ENSG00000196338ENST00000536169Q9NZ94
ENSG00000196338ENST00000536169X5D7L6
ENSG00000196338ENST00000612180A0A087WW27

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382542062024Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.0
382724502024Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation.0
382542062024Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.0
382724502024Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation.0
368109322023Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency.3
378802212023Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Gαi1/3-Akt signaling.0
368109322023Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency.3
378802212023Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Gαi1/3-Akt signaling.0
364792162022Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.2
364792162022Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.2
343737572021Neuronal-driven glioma growth requires Gαi1 and Gαi3.33
343737572021Neuronal-driven glioma growth requires Gαi1 and Gαi3.33
317058952020Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders.6
317058952020Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders.6
311198672019Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3.41

Citation

Dessen P

NLGN3 (neuroligin 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55751/nlgn3-(neuroligin-3)