KIR2DL4 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4)

2016-05-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
CD158D,G9P,KIR-103AS,KIR-2DL4,KIR103,KIR103AS

Other Information

Locus ID:

NCBI: 3805
MIM: 604945
HGNC: 6332
Ensembl: ENSG00000189013

Variants:

dbSNP: 3805
ClinVar: 3805
TCGA: ENSG00000189013
COSMIC: KIR2DL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189013ENST00000345540Q99706
ENSG00000189013ENST00000345540A0A376A929
ENSG00000189013ENST00000346587Q8N736
ENSG00000189013ENST00000357494Q99706
ENSG00000189013ENST00000357494A0A376A8K3
ENSG00000189013ENST00000359085A0A0B4J1S6
ENSG00000189013ENST00000396284E7EST5
ENSG00000189013ENST00000396289A8MT18
ENSG00000189013ENST00000396293Q99706

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Natural killer cell mediated cytotoxicityKEGGko04650
Antigen processing and presentationKEGGhsa04612
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
379449952024Underrepresentation of activating KIR gene expression in single-cell RNA-seq data is due to KIR gene misassignment.0
379449952024Underrepresentation of activating KIR gene expression in single-cell RNA-seq data is due to KIR gene misassignment.0
368906452023KIR2DL4/HLA-G polymorphisms were associated with HCV infection susceptibility among Chinese high-risk population.0
368906452023KIR2DL4/HLA-G polymorphisms were associated with HCV infection susceptibility among Chinese high-risk population.0
350634662022KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation.3
351858872022Roles of HLA-G/KIR2DL4 in Breast Cancer Immune Microenvironment.12
358488982022Clinical significance and immune landscape of KIR2DL4 and the senescence-based signature in cutaneous melanoma.3
350634662022KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation.3
351858872022Roles of HLA-G/KIR2DL4 in Breast Cancer Immune Microenvironment.12
358488982022Clinical significance and immune landscape of KIR2DL4 and the senescence-based signature in cutaneous melanoma.3
341584752021Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.34
341584752021Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.34
320239402020Killer Immunoglobulin-Like Receptor 2DL4 (CD158d) Regulates Human Mast Cells both Positively and Negatively: Possible Roles in Pregnancy and Cancer Metastasis.8
322461542020Family-based exome sequencing identifies rare coding variants in age-related macular degeneration.16
327112262020Possible roles of HLA-G regulating immune cells in pregnancy and endometrial diseases via KIR2DL4.10

Citation

Dessen P

KIR2DL4 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55769/kir2dl4-(killer-cell-immunoglobulin-like-receptor-two-ig-domains-and-long-cytoplasmic-tail-4)