VAMP2 (vesicle associated membrane protein 2)

2016-05-01 Affiliation

Identity

HGNC

VAMP2

LOCATION

17p13.1

LOCUSID

6844

ALIAS

NEDHAHM,SYB2,VAMP-2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6844
MIM: 185881
HGNC: 12643
Ensembl: ENSG00000220205

Variants:

dbSNP: 6844
ClinVar: 6844
TCGA: ENSG00000220205
COSMIC: VAMP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000220205	ENST00000316509	P63027
ENSG00000220205	ENST00000404970	K7ENK9
ENSG00000220205	ENST00000481878	J3QRU4
ENSG00000220205	ENST00000488857	F8WCA0

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
SNARE interactions in vesicular transport	KEGG	ko04130
SNARE interactions in vesicular transport	KEGG	hsa04130
Vasopressin-regulated water reabsorption	KEGG	ko04962
Vasopressin-regulated water reabsorption	KEGG	hsa04962
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Synaptic vesicle cycle	KEGG	ko04721
Synaptic vesicle cycle	KEGG	hsa04721
Insulin secretion	KEGG	hsa04911
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Insulin processing	REACTOME	R-HSA-264876
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Release Cycle	REACTOME	R-HSA-112310
Norepinephrine Neurotransmitter Release Cycle	REACTOME	R-HSA-181430
Serotonin Neurotransmitter Release Cycle	REACTOME	R-HSA-181429
Glutamate Neurotransmitter Release Cycle	REACTOME	R-HSA-210500
Dopamine Neurotransmitter Release Cycle	REACTOME	R-HSA-212676
Acetylcholine Neurotransmitter Release Cycle	REACTOME	R-HSA-264642
GABA synthesis, release, reuptake and degradation	REACTOME	R-HSA-888590
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Uptake and actions of bacterial toxins	REACTOME	R-HSA-5339562
Neurotoxicity of clostridium toxins	REACTOME	R-HSA-168799
Toxicity of botulinum toxin type B (BoNT/B)	REACTOME	R-HSA-5250958
Toxicity of tetanus toxin (TeNT)	REACTOME	R-HSA-5250982
Toxicity of botulinum toxin type D (BoNT/D)	REACTOME	R-HSA-5250955
Toxicity of botulinum toxin type F (BoNT/F)	REACTOME	R-HSA-5250981
Toxicity of botulinum toxin type G (BoNT/G)	REACTOME	R-HSA-5250989
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
trans-Golgi Network Vesicle Budding	REACTOME	R-HSA-199992
Clathrin derived vesicle budding	REACTOME	R-HSA-421837
Golgi Associated Vesicle Biogenesis	REACTOME	R-HSA-432722
Lysosome Vesicle Biogenesis	REACTOME	R-HSA-432720
Translocation of GLUT4 to the plasma membrane	REACTOME	R-HSA-1445148
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825

References

Pubmed ID	Year	Title	Citations
18182011	2008	Evidence for CALM in directing VAMP2 trafficking.	57
17001002	2006	Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion.	55
21808019	2011	SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.	55
19557857	2009	De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy.	42
20471030	2010	Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.	42
22172278	2012	Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5.	31
18511417	2008	Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin.	29
20416077	2010	Identification of type 2 diabetes-associated combination of SNPs using support vector machine.	26
26412491	2015	Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.	23
18511418	2008	Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.	20

Citation

Dessen P

VAMP2 (vesicle associated membrane protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55772/vamp2-(vesicle-associated-membrane-protein-2)