VAMP2 (vesicle associated membrane protein 2)

2016-05-01  

Identity

HGNC
VAMP2
LOCATION
17p13.1
LOCUSID
6844
ALIAS
NEDHAHM,SYB2,VAMP-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6844
MIM: 185881
HGNC: 12643
Ensembl: ENSG00000220205

Variants:

dbSNP: 6844
ClinVar: 6844
TCGA: ENSG00000220205
COSMIC: VAMP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000220205ENST00000316509P63027
ENSG00000220205ENST00000404970K7ENK9
ENSG00000220205ENST00000481878J3QRU4
ENSG00000220205ENST00000488857F8WCA0

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
Insulin secretionKEGGhsa04911
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Norepinephrine Neurotransmitter Release CycleREACTOMER-HSA-181430
Serotonin Neurotransmitter Release CycleREACTOMER-HSA-181429
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500
Dopamine Neurotransmitter Release CycleREACTOMER-HSA-212676
Acetylcholine Neurotransmitter Release CycleREACTOMER-HSA-264642
GABA synthesis, release, reuptake and degradationREACTOMER-HSA-888590
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Neurotoxicity of clostridium toxinsREACTOMER-HSA-168799
Toxicity of botulinum toxin type B (BoNT/B)REACTOMER-HSA-5250958
Toxicity of tetanus toxin (TeNT)REACTOMER-HSA-5250982
Toxicity of botulinum toxin type D (BoNT/D)REACTOMER-HSA-5250955
Toxicity of botulinum toxin type F (BoNT/F)REACTOMER-HSA-5250981
Toxicity of botulinum toxin type G (BoNT/G)REACTOMER-HSA-5250989
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

References

Pubmed IDYearTitleCitations
373809512023Non-coding variants in VAMP2 and SNAP25 affect gene expression: potential implications in migraine susceptibility.0
378987602023Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer's disease continuum.0
373809512023Non-coding variants in VAMP2 and SNAP25 affect gene expression: potential implications in migraine susceptibility.0
378987602023Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer's disease continuum.0
363807322022α-Synuclein Disrupts Vesicle Fusion by Two Mutant-Specific Mechanisms.2
363807322022α-Synuclein Disrupts Vesicle Fusion by Two Mutant-Specific Mechanisms.2
332175622021Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease.38
341830502021VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome.3
341900412021The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores.16
350688712021Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma.10
332175622021Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease.38
341830502021VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome.3
341900412021The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores.16
350688712021Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma.10
321941322020Ceramide induces a multicomponent intracellular calcium increase triggering the acrosome secretion in human sperm.8

Citation

Dessen P

VAMP2 (vesicle associated membrane protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55772/vamp2-(vesicle-associated-membrane-protein-2)