PPFIBP2 (PPFIA binding protein 2)

2016-05-01  

Identity

HGNC
PPFIBP2
LOCATION
11p15.4
LOCUSID
8495
ALIAS
Cclp1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8495
MIM: 603142
HGNC: 9250
Ensembl: ENSG00000166387

Variants:

dbSNP: 8495
ClinVar: 8495
TCGA: ENSG00000166387
COSMIC: PPFIBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166387ENST00000299492Q8ND30
ENSG00000166387ENST00000524548H0YDM0
ENSG00000166387ENST00000525597E9PJA0
ENSG00000166387ENST00000526046E9PMN3
ENSG00000166387ENST00000526873E9PK17
ENSG00000166387ENST00000527790E9PMH3
ENSG00000166387ENST00000528883Q8ND30
ENSG00000166387ENST00000528947E9PK17
ENSG00000166387ENST00000529575E9PIK8
ENSG00000166387ENST00000530081E9PI79
ENSG00000166387ENST00000530181Q8ND30
ENSG00000166387ENST00000533792E9PP16
ENSG00000166387ENST00000534409H0YDJ2
ENSG00000166387ENST00000534552H0YET1
ENSG00000166387ENST00000650027A0A3B3IS15

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
223285292012ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2.25
264434492015Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.19
200958542010Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.16
266633472016Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells.8
214629292011Crystal structure of the central coiled-coil domain from human liprin-β2.2
300434172018Germline mutations in PPFIBP2 are associated with lethal prostate cancer.1

Citation

Dessen P

PPFIBP2 (PPFIA binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55776/ppfibp2-(ppfia-binding-protein-2)