Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64374
MIM: 608005
HGNC: 24624
Ensembl: ENSG00000120725
Variants:
dbSNP: 64374
ClinVar: 64374
TCGA: ENSG00000120725
COSMIC: SIL1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Protein processing in endoplasmic reticulum | KEGG | ko04141 |
| Protein processing in endoplasmic reticulum | KEGG | hsa04141 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 39060875 | 2024 | Exome sequencing revealed variants in SGCA and SIL1 genes underlying limb girdle muscular dystrophy and Marinesco-Sjögren syndrome patients. | 0 |
| 39060875 | 2024 | Exome sequencing revealed variants in SGCA and SIL1 genes underlying limb girdle muscular dystrophy and Marinesco-Sjögren syndrome patients. | 0 |
| 37116165 | 2023 | Down-regulation and Clinic-pathological Correlation of SIK-1 and SIK-1-LNC in Non-small Cell Lung Cancer Patients. | 0 |
| 37116165 | 2023 | Down-regulation and Clinic-pathological Correlation of SIK-1 and SIK-1-LNC in Non-small Cell Lung Cancer Patients. | 0 |
| 34830330 | 2021 | Proteomic Analysis of Marinesco-Sjogren Syndrome Fibroblasts Indicates Pro-Survival Metabolic Adaptation to SIL1 Loss. | 7 |
| 34830330 | 2021 | Proteomic Analysis of Marinesco-Sjogren Syndrome Fibroblasts Indicates Pro-Survival Metabolic Adaptation to SIL1 Loss. | 7 |
| 31791191 | 2020 | Nucleotide exchange factor SIL1 promotes the progress of breast cancer cells via regulating the cell cycle and apoptosis. | 5 |
| 31791191 | 2020 | Nucleotide exchange factor SIL1 promotes the progress of breast cancer cells via regulating the cell cycle and apoptosis. | 5 |
| 30468864 | 2019 | SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human. | 7 |
| 30468864 | 2019 | SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human. | 7 |
| 29323281 | 2018 | Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate. | 19 |
| 30293566 | 2018 | PERK inhibition attenuates the abnormalities of the secretory pathway and the increased apoptotic rate induced by SIL1 knockdown in HeLa cells. | 5 |
| 29323281 | 2018 | Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate. | 19 |
| 30293566 | 2018 | PERK inhibition attenuates the abnormalities of the secretory pathway and the increased apoptotic rate induced by SIL1 knockdown in HeLa cells. | 5 |
| 26468156 | 2016 | Cellular Signature of SIL1 Depletion: Disease Pathogenesis due to Alterations in Protein Composition Beyond the ER Machinery. | 19 |
Citation
Dessen P
SIL1 (SIL1 nucleotide exchange factor)
Atlas Genet Cytogenet Oncol Haematol. 2016-05-01
Online version: http://atlasgeneticsoncology.org/gene/55779/sil1-(sil1-nucleotide-exchange-factor)
