CMTM4 (CKLF like MARVEL transmembrane domain containing 4)

2016-08-01  

Identity

HGNC
CMTM4
LOCATION
16q22.1
LOCUSID
146223
ALIAS
CKLFSF4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 146223
MIM: 607887
HGNC: 19175
Ensembl: ENSG00000183723

Variants:

dbSNP: 146223
ClinVar: 146223
TCGA: ENSG00000183723
COSMIC: CMTM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183723ENST00000330687Q8IZR5
ENSG00000183723ENST00000394106Q8IZR5
ENSG00000183723ENST00000561680J3QRP2
ENSG00000183723ENST00000563952Q8IZR5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
288134102017Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.76
127821302003Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.31
202133162010Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation.14
264745602015CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma.11
300978102019CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions.9
314356382019CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2, and STAT3 pathway in colorectal cancer.0

Citation

Dessen P

CMTM4 (CKLF like MARVEL transmembrane domain containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55827/cmtm4-(cklf-like-marvel-transmembrane-domain-containing-4)