DHRS9 (dehydrogenase/reductase 9)

2016-08-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
3-alpha-HSD,3ALPHA-HSD,RDH-E2,RDH-TBE,RDH15,RDHL,RDHTBE,RETSDR8,SDR9C4
FUSION GENES

Other Information

Locus ID:

NCBI: 10170
MIM: 612131
HGNC: 16888
Ensembl: ENSG00000073737

Variants:

dbSNP: 10170
ClinVar: 10170
TCGA: ENSG00000073737
COSMIC: DHRS9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073737ENST00000357546Q9BPW9
ENSG00000073737ENST00000412271Q9BPW9
ENSG00000073737ENST00000421653Q9BPW9
ENSG00000073737ENST00000428522Q9BPW9
ENSG00000073737ENST00000432060Q9BPW9
ENSG00000073737ENST00000436483Q9BPW9
ENSG00000073737ENST00000450153C9J430
ENSG00000073737ENST00000602501Q9BPW9

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The canonical retinoid cycle in rods (twilight vision)REACTOMER-HSA-2453902
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
363402692022Transcription Factor FXR Activates DHRS9 to Inhibit the Cell Oxidative Phosphorylation and Suppress Colon Cancer Progression.1
363402692022Transcription Factor FXR Activates DHRS9 to Inhibit the Cell Oxidative Phosphorylation and Suppress Colon Cancer Progression.1
327523002020Are Mutations in the DHRS9 Gene Causally Linked to Epilepsy? A Case Report.2
327523002020Are Mutations in the DHRS9 Gene Causally Linked to Epilepsy? A Case Report.2
301499922018Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma.14
301499922018Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma.14
285947512017DHRS9 Is a Stable Marker of Human Regulatory Macrophages.39
285947512017DHRS9 Is a Stable Marker of Human Regulatory Macrophages.39
262540992016Downregulation of DHRS9 expression in colorectal cancer tissues and its prognostic significance.12
272398452016[Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer].8
262540992016Downregulation of DHRS9 expression in colorectal cancer tissues and its prognostic significance.12
272398452016[Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer].8
172446232007Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9.24
172446232007Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9.24
166911982006A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity.8

Citation

Dessen P

DHRS9 (dehydrogenase/reductase 9)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55832/dhrs9-(dehydrogenase-reductase-9)