SERPING1 (serpin family G member 1)

2016-08-01  

Identity

HGNC
LOCATION
11q12.1
LOCUSID
ALIAS
C1IN,C1INH,C1NH,HAE1,HAE2
FUSION GENES

Other Information

Locus ID:

NCBI: 710
MIM: 606860
HGNC: 1228
Ensembl: ENSG00000149131

Variants:

dbSNP: 710
ClinVar: 710
TCGA: ENSG00000149131
COSMIC: SERPING1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149131ENST00000278407P05155
ENSG00000149131ENST00000278407E9KL26
ENSG00000149131ENST00000340687H9KV48
ENSG00000149131ENST00000378323P05155
ENSG00000149131ENST00000378324P05155
ENSG00000149131ENST00000378324A0A348GSH7
ENSG00000149131ENST00000403558E9PGN7
ENSG00000149131ENST00000405496B5MCB9
ENSG00000149131ENST00000457869C9JZJ9
ENSG00000149131ENST00000528996H0YCA1
ENSG00000149131ENST00000531133E9PK97
ENSG00000149131ENST00000531797E9PK97
ENSG00000149131ENST00000619430A0A087WUD9

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
PertussisKEGGko05133
PertussisKEGGhsa05133
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381820982024Comorbidities in Angioedema Due to C1-Inhibitor Deficiency: An Italian Survey.0
382549612024Cerebrospinal Fluid C1-Esterase Inhibitor and Tie-1 Levels Affect Cognitive Performance: Evidence from Proteome-Wide Mendelian Randomization.0
381820982024Comorbidities in Angioedema Due to C1-Inhibitor Deficiency: An Italian Survey.0
382549612024Cerebrospinal Fluid C1-Esterase Inhibitor and Tie-1 Levels Affect Cognitive Performance: Evidence from Proteome-Wide Mendelian Randomization.0
363856782023Interplay between C1-inhibitor and group IIA secreted phospholipase A(2) impairs their respective function.0
367878262023Gene Mutations Linked to Hereditary Angioedema in Solitary Angioedema Patients With Normal C1 Inhibitor.1
376207422023Systematic Approach Revealed SERPING1 Splicing-Affecting Variants to be Highly Represented in the Czech National HAE Cohort.3
377165252023Acquired Angioedema Due to C1-Inhibitor Deficiency (AAE-C1-INH)-A Bicenter Retrospective Study on Diagnosis, Course, and Therapy.0
363856782023Interplay between C1-inhibitor and group IIA secreted phospholipase A(2) impairs their respective function.0
367878262023Gene Mutations Linked to Hereditary Angioedema in Solitary Angioedema Patients With Normal C1 Inhibitor.1
376207422023Systematic Approach Revealed SERPING1 Splicing-Affecting Variants to be Highly Represented in the Czech National HAE Cohort.3
377165252023Acquired Angioedema Due to C1-Inhibitor Deficiency (AAE-C1-INH)-A Bicenter Retrospective Study on Diagnosis, Course, and Therapy.0
328961912022Genetic Study of Hereditary Angioedema Type I and Type II (First Report from Iranian Patients: Describing Three New Mutations).3
343486032022C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development.10
348440232022Angioedema Due to Acquired Deficiency of C1-Inhibitor: A Cohort Study in Spain and a Comparison With Other Series.6

Citation

Dessen P

SERPING1 (serpin family G member 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55836/serping1-(serpin-family-g-member-1)