LSM2 (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)

2016-08-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
C6orf28,G7B,YBL026W,snRNP

Other Information

Locus ID:

NCBI: 57819
MIM: 607282
HGNC: 13940
Ensembl: ENSG00000204392

Variants:

dbSNP: 57819
ClinVar: 57819
TCGA: ENSG00000204392
COSMIC: LSM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204392ENST00000375661Q9Y333

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U4/U6.U5 tri-snRNPKEGGhsa_M00354
Lsm 2-8 complexKEGGhsa_M00396
Lsm 1-7 complexKEGGhsa_M00397
Spliceosome, U4/U6.U5 tri-snRNPKEGGM00354
Lsm 2-8 complexKEGGM00396
Lsm 1-7 complexKEGGM00397
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA Splicing - Minor PathwayREACTOMER-HSA-72165
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373121862023LSM2 is associated with a poor prognosis and promotes cell proliferation, migration, and invasion in skin cutaneous melanoma.3
376124792023The mechanism of LSM2 in the progression of live hepatocellular carcinoma was analyzed based on bioinformatics.0
373121862023LSM2 is associated with a poor prognosis and promotes cell proliferation, migration, and invasion in skin cutaneous melanoma.3
376124792023The mechanism of LSM2 in the progression of live hepatocellular carcinoma was analyzed based on bioinformatics.0
262610202015Small nuclear ribonucleoprotein associated polypeptide N accelerates cell proliferation in pancreatic adenocarcinoma.5
262610202015Small nuclear ribonucleoprotein associated polypeptide N accelerates cell proliferation in pancreatic adenocarcinoma.5
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.58
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.58
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
180951542008Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.10
180951542008Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.10
125153822002The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.203

Citation

Dessen P

LSM2 (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55839/lsm2-(lsm2-homolog-u6-small-nuclear-rna-and-mrna-degradation-associated)