CTDP1 (CTD phosphatase subunit 1)

2016-08-01  

Identity

HGNC
LOCATION
18q23
LOCUSID
ALIAS
CCFDN,FCP1
FUSION GENES

Other Information

Locus ID:

NCBI: 9150
MIM: 604927
HGNC: 2498
Ensembl: ENSG00000060069

Variants:

dbSNP: 9150
ClinVar: 9150
TCGA: ENSG00000060069
COSMIC: CTDP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000060069ENST00000075430Q9Y5B0
ENSG00000060069ENST00000299543A0A0A0MR03
ENSG00000060069ENST00000590635K7EPW4
ENSG00000060069ENST00000591598K7EJD2
ENSG00000060069ENST00000613122Q9Y5B0

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription ElongationREACTOMER-HSA-167169
Formation of the HIV-1 Early Elongation ComplexREACTOMER-HSA-167158
Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
Abortive elongation of HIV-1 transcript in the absence of TatREACTOMER-HSA-167242
HIV elongation arrest and recoveryREACTOMER-HSA-167287
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Pausing and recovery of HIV elongationREACTOMER-HSA-167290
Tat-mediated HIV elongation arrest and recoveryREACTOMER-HSA-167243
Pausing and recovery of Tat-mediated HIV elongationREACTOMER-HSA-167238
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of the Early Elongation ComplexREACTOMER-HSA-113418
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
277773412017Identification of Novel Biomarkers for Behcet Disease Diagnosis Using Human Proteome Microarray Approach.29
277773412017Identification of Novel Biomarkers for Behcet Disease Diagnosis Using Human Proteome Microarray Approach.29
265905732016Lentivirus-mediated knockdown of CTDP1 inhibits lung cancer cell growth in vitro.2
265905732016Lentivirus-mediated knockdown of CTDP1 inhibits lung cancer cell growth in vitro.2
226925372012Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit.33
226925372012Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit.33
216725232011The disordered C-terminus of the RNA polymerase II phosphatase FCP1 is partially helical in the unbound state.5
216725232011The disordered C-terminus of the RNA polymerase II phosphatase FCP1 is partially helical in the unbound state.5
192150942009NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase.6
198886852009NMR assignment of the intrinsically disordered C-terminal region of Homo sapiens FCP1 in the unbound state.1
192150942009NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase.6
198886852009NMR assignment of the intrinsically disordered C-terminal region of Homo sapiens FCP1 in the unbound state.1
182944532008Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II.18
182944532008Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II.18
156708292005Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation.34

Citation

Dessen P

CTDP1 (CTD phosphatase subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55851/meetings/deep-insight-explorer/