NADK (NAD kinase)

2016-08-01  

Identity

HGNC
NADK
LOCATION
1p36.33
LOCUSID
65220
ALIAS
dJ283E3.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 65220
MIM: 611616
HGNC: 29831
Ensembl: ENSG00000008130

Variants:

dbSNP: 65220
ClinVar: 65220
TCGA: ENSG00000008130
COSMIC: NADK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008130ENST00000341426O95544
ENSG00000008130ENST00000341426A0A024R058
ENSG00000008130ENST00000341991O95544
ENSG00000008130ENST00000341991A0A024R058
ENSG00000008130ENST00000342348A0A0A0MR98
ENSG00000008130ENST00000378625O95544
ENSG00000008130ENST00000469045J3KSP9
ENSG00000008130ENST00000489538J3KTI3
ENSG00000008130ENST00000497186J3QR86
ENSG00000008130ENST00000498806J3QRC0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Nicotinate and nicotinamide metabolismKEGGko00760
Nicotinate and nicotinamide metabolismKEGGhsa00760
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383154512024G-protein-coupled estrogen receptor 1 promotes peritoneal metastasis of gastric cancer through nicotinamide adenine dinucleotide kinase 1-mediated redox modulation.0
387005332024Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis.1
383154512024G-protein-coupled estrogen receptor 1 promotes peritoneal metastasis of gastric cancer through nicotinamide adenine dinucleotide kinase 1-mediated redox modulation.0
387005332024Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis.1
341339372021NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.13
341339372021NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.13
308465982019Direct stimulation of NADP(+) synthesis through Akt-mediated phosphorylation of NAD kinase.63
308465982019Direct stimulation of NADP(+) synthesis through Akt-mediated phosphorylation of NAD kinase.63
289547332017Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers.59
289547332017Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers.59
268060152016Functional annotation of rare gene aberration drivers of pancreatic cancer.43
268060152016Functional annotation of rare gene aberration drivers of pancreatic cancer.43
265774082015Significance of Ser-188 in human mitochondrial NAD kinase as determined by phosphomimetic and phosphoresistant amino-acid substitutions.5
265774082015Significance of Ser-188 in human mitochondrial NAD kinase as determined by phosphomimetic and phosphoresistant amino-acid substitutions.5
215263402011NADPH regulates human NAD kinase, a NADP⁺-biosynthetic enzyme.11

Citation

Dessen P

NADK (NAD kinase)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55853/nadk-(nad-kinase)