HOXB1 (homeobox B1)

2016-08-01  

Identity

HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
HCFP3,HOX2,HOX2I,Hox-2.9

Other Information

Locus ID:

NCBI: 3211
MIM: 142968
HGNC: 5111
Ensembl: ENSG00000120094

Variants:

dbSNP: 3211
ClinVar: 3211
TCGA: ENSG00000120094
COSMIC: HOXB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120094ENST00000239174P14653
ENSG00000120094ENST00000577092P14653

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
344885452021MicroRNA-301b-3p facilitates cell proliferation and migration in colorectal cancer by targeting HOXB1.5
344885452021MicroRNA-301b-3p facilitates cell proliferation and migration in colorectal cancer by targeting HOXB1.5
321021212020The MicroRNA hsa-let-7g Promotes Proliferation and Inhibits Apoptosis in Lung Cancer by Targeting HOXB1.11
321021212020The MicroRNA hsa-let-7g Promotes Proliferation and Inhibits Apoptosis in Lung Cancer by Targeting HOXB1.11
299231542018Analysis of HOXB1 gene in a cohort of patients with sporadic ventricular septal defect.1
299231542018Analysis of HOXB1 gene in a cohort of patients with sporadic ventricular septal defect.1
276409202017A novel homozygous HOXB1 mutation in a Turkish family with hereditary congenital facial paresis.4
276409202017A novel homozygous HOXB1 mutation in a Turkish family with hereditary congenital facial paresis.4
271449142016Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis.11
271449142016Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis.11
265656242015HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma.15
265656242015HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma.15
227709812012HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice.32
227709812012HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice.32
214332212011Anterior Hox genes interact with components of the neural crest specification network to induce neural crest fates.14

Citation

Dessen P

HOXB1 (homeobox B1)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55862/hoxb1-(homeobox-b1)