CORT (cortistatin)

2016-08-01 Affiliation

Identity

HGNC

CORT

LOCATION

1p36.22

LOCUSID

1325

ALIAS

CST-14,CST-17,CST-29,SST2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1325
MIM: 602784
HGNC: 2257
Ensembl: ENSG00000241563

Variants:

dbSNP: 1325
ClinVar: 1325
TCGA: ENSG00000241563
COSMIC: CORT

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000241563	ENST00000377049	O00230

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

References

Pubmed ID	Year	Title	Citations
12915402	2003	MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.	43
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
12684217	2003	Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells.	33
20398908	2010	Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.	32
18709137	2008	Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation.	18
20164562	2010	Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.	18
16043736	2005	Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects.	13
12519865	2003	Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system.	9
18450367	2008	The role of cortistatin in the human immune system.	6
12161511	2002	Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans.	4

Citation

Dessen P

CORT (cortistatin)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55863/cort-(cortistatin)