CORT (cortistatin)

2016-08-01  

Identity

HGNC
LOCATION
1p36.22
LOCUSID
ALIAS
CST-14,CST-17,CST-29,SST2
FUSION GENES

Other Information

Locus ID:

NCBI: 1325
MIM: 602784
HGNC: 2257
Ensembl: ENSG00000241563

Variants:

dbSNP: 1325
ClinVar: 1325
TCGA: ENSG00000241563
COSMIC: CORT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241563ENST00000377049O00230

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
377944932023Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity.2
377944932023Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity.2
363617902022Somatostatin, Cortistatin and Their Receptors Exert Antitumor Actions in Androgen-Independent Prostate Cancer Cells: Critical Role of Endogenous Cortistatin.2
363617902022Somatostatin, Cortistatin and Their Receptors Exert Antitumor Actions in Androgen-Independent Prostate Cancer Cells: Critical Role of Endogenous Cortistatin.2
311548792020Decreased maternal serum cortistatin levels in pregnancies with gestational diabetes mellitus.3
315745072020Cytoskeleton Protein Filamin A Is Required for Efficient Somatostatin Receptor Type 2 Internalization and Recycling through Rab5 and Rab4 Sorting Endosomes in Tumor Somatotroph Cells.9
323543562020Comparison of predictive value of NT-proBNP, sST2 and MMPs in heart failure patients with different ejection fractions.13
325509192020Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation.53
311548792020Decreased maternal serum cortistatin levels in pregnancies with gestational diabetes mellitus.3
315745072020Cytoskeleton Protein Filamin A Is Required for Efficient Somatostatin Receptor Type 2 Internalization and Recycling through Rab5 and Rab4 Sorting Endosomes in Tumor Somatotroph Cells.9
323543562020Comparison of predictive value of NT-proBNP, sST2 and MMPs in heart failure patients with different ejection fractions.13
325509192020Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation.53
308263582019Cortistatin binds to TNF-α receptors and protects against osteoarthritis.29
308263582019Cortistatin binds to TNF-α receptors and protects against osteoarthritis.29
285265562017Circulating levels of cortistatin are correlated with metabolic parameters in patients with newly diagnosed type 2 diabetes mellitus.3

Citation

Dessen P

CORT (cortistatin)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55863/cort-(cortistatin)