NOP14 (NOP14 nucleolar protein)

2016-08-01  

Identity

HGNC
LOCATION
4p16.3
LOCUSID
ALIAS
C4orf9,NOL14,RES4-25,RES425,UTP2

Other Information

Locus ID:

NCBI: 8602
MIM: 611526
HGNC: 16821
Ensembl: ENSG00000087269

Variants:

dbSNP: 8602
ClinVar: 8602
TCGA: ENSG00000087269
COSMIC: NOP14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087269ENST00000314262P78316
ENSG00000087269ENST00000398071P78316
ENSG00000087269ENST00000416614P78316
ENSG00000087269ENST00000502735E9PFK5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382722242024NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity.0
382722242024NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity.0
354736112022Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.2
354736112022Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.2
342186532021NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway.3
342186532021NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway.3
319716542020CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.25
319716542020CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.25
294407062018A homozygous NOP14 variant is likely to cause recurrent pregnancy loss.4
294407062018A homozygous NOP14 variant is likely to cause recurrent pregnancy loss.4
282800382017Pancreatic Cancer Progression Relies upon Mutant p53-Induced Oncogenic Signaling Mediated by NOP14.21
282800382017Pancreatic Cancer Progression Relies upon Mutant p53-Induced Oncogenic Signaling Mediated by NOP14.21
262138462015NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway.18
262138462015NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway.18
224257612012NOP14 promotes proliferation and metastasis of pancreatic cancer cells.14

Citation

Dessen P

NOP14 (NOP14 nucleolar protein)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55865/nop14-(nop14-nucleolar-protein)