Identity
HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
1D,64kD,D1,SM-LMOD,SMLMOD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 25802
MIM: 602715
HGNC: 6647
Ensembl: ENSG00000163431
Variants:
dbSNP: 25802
ClinVar: 25802
TCGA: ENSG00000163431
COSMIC: LMOD1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000163431 | ENST00000367288 | P29536 |
| ENSG00000163431 | ENST00000616739 | Q9BV00 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Muscle contraction | REACTOME | R-HSA-397014 |
| Smooth Muscle Contraction | REACTOME | R-HSA-445355 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38849852 | 2024 | Spatiotemporal heterogeneity of LMOD1 expression summarizes two modes of cell communication in colorectal cancer. | 0 |
| 38849852 | 2024 | Spatiotemporal heterogeneity of LMOD1 expression summarizes two modes of cell communication in colorectal cancer. | 0 |
| 35170814 | 2022 | Loss-of-function variants within LMOD1 actin-binding site 2 cause pediatric intestinal pseudo-obstruction by impairing protein stability and actin nucleation. | 0 |
| 35488236 | 2022 | LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway. | 3 |
| 35170814 | 2022 | Loss-of-function variants within LMOD1 actin-binding site 2 cause pediatric intestinal pseudo-obstruction by impairing protein stability and actin nucleation. | 0 |
| 35488236 | 2022 | LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway. | 3 |
| 30444878 | 2018 | Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. | 24 |
| 30444878 | 2018 | Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. | 24 |
| 28292896 | 2017 | Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice. | 50 |
| 28292896 | 2017 | Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice. | 50 |
| 27144530 | 2016 | MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension. | 29 |
| 27470516 | 2016 | Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. | 40 |
| 27144530 | 2016 | MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension. | 29 |
| 27470516 | 2016 | Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. | 40 |
| 22157009 | 2012 | Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells. | 59 |
Citation
Dessen P
LMOD1 (leiomodin 1)
Atlas Genet Cytogenet Oncol Haematol. 2016-08-01
Online version: http://atlasgeneticsoncology.org/gene/55867/lmod1-(leiomodin-1)
