BLVRB (biliverdin reductase B)

2016-08-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
BVRB,FLR,HEL-S-10,SDR43U1
FUSION GENES

Other Information

Locus ID:

NCBI: 645
MIM: 600941
HGNC: 1063
Ensembl: ENSG00000090013

Variants:

dbSNP: 645
ClinVar: 645
TCGA: ENSG00000090013
COSMIC: BLVRB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090013ENST00000263368P30043
ENSG00000090013ENST00000263368V9HWI1
ENSG00000090013ENST00000595483M0R192
ENSG00000090013ENST00000597870M0QZL1
ENSG00000090013ENST00000643519A0A2R8YEP4
ENSG00000090013ENST00000643596A0A2R8Y7Y9

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Riboflavin metabolismKEGGko00740
Porphyrin and chlorophyll metabolismKEGGko00860
Riboflavin metabolismKEGGhsa00740
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of porphyrinsREACTOMER-HSA-189445
Heme degradationREACTOMER-HSA-189483

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA450457methylene blueChemicalLabelAnnotation, Pathwayassociated23913015

References

Pubmed IDYearTitleCitations
257263842015Biliverdin reductase isozymes in metabolism.31
267081472016MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-κB pathway to suppress cell growth in hepatocellular carcinoma cells.15
182412012008Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase.10
272077952016BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans.4
294871332018<i>In silico</i> and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency.0
295002322018Heme degradation enzyme biliverdin IXβ reductase is required for stem cell glutamine metabolism.0

Citation

Dessen P

BLVRB (biliverdin reductase B)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55876/blvrb-(biliverdin-reductase-b)