PROKR1 (prokineticin receptor 1)

2016-08-01  

Identity

HGNC
PROKR1
LOCATION
2p13.3
LOCUSID
10887
ALIAS
GPR73,GPR73a,PK-R1,PKR1,ZAQ
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10887
MIM: 607122
HGNC: 4524
Ensembl: ENSG00000169618

Variants:

dbSNP: 10887
ClinVar: 10887
TCGA: ENSG00000169618
COSMIC: PROKR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169618ENST00000303786Q8TCW9

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
331849292021Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.5
338119882021Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.5
331849292021Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.5
338119882021Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.5
325853942020The role of prokineticins in recurrent implantation failure.3
325853942020The role of prokineticins in recurrent implantation failure.3
313049222019[Expression of PROK 1 and its receptor PROKR 1 in endometriosis and its clinical significance].3
313049222019[Expression of PROK 1 and its receptor PROKR 1 in endometriosis and its clinical significance].3
269848422016Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.2
269848422016Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.2
261928752015Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.2
264753022015Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.6
265748952015Prokineticins in central and peripheral control of human reproduction.11
261928752015Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.2
264753022015Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.6

Citation

Dessen P

PROKR1 (prokineticin receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55884/prokr1-(prokineticin-receptor-1)