PFDN1 (prefoldin subunit 1)

2016-08-01  

Identity

HGNC
PFDN1
LOCATION
5q31.3
LOCUSID
5201
ALIAS
PDF,PFD1

Other Information

Locus ID:

NCBI: 5201
MIM: 604897
HGNC: 8866
Ensembl: ENSG00000113068

Variants:

dbSNP: 5201
ClinVar: 5201
TCGA: ENSG00000113068
COSMIC: PFDN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113068ENST00000261813O60925
ENSG00000113068ENST00000510217D6RGG5
ENSG00000113068ENST00000524074E5RGS4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352172672022Prefoldin and prefoldin-like complex subunits as predictive biomarkers for hepatocellular carcinoma immunotherapy.2
352172672022Prefoldin and prefoldin-like complex subunits as predictive biomarkers for hepatocellular carcinoma immunotherapy.2
276948982017Prefoldin 1 promotes EMT and lung cancer progression by suppressing cyclin A expression.35
281835282017Transethnic genome-wide scan identifies novel Alzheimer's disease loci.111
276948982017Prefoldin 1 promotes EMT and lung cancer progression by suppressing cyclin A expression.35
281835282017Transethnic genome-wide scan identifies novel Alzheimer's disease loci.111
265533182015PFDN1, an indicator for colorectal cancer prognosis, enhances tumor cell proliferation and motility through cytoskeletal reorganization.22
265533182015PFDN1, an indicator for colorectal cancer prognosis, enhances tumor cell proliferation and motility through cytoskeletal reorganization.22
164153412006PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.39
164153412006PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.39

Citation

Dessen P

PFDN1 (prefoldin subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55901/pfdn1-(prefoldin-subunit-1)