SLAMF7 (SLAM family member 7)

2016-08-01  

Identity

HGNC
SLAMF7
LOCATION
1q23.3
LOCUSID
57823
ALIAS
19A,CD319,CRACC,CS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57823
MIM: 606625
HGNC: 21394
Ensembl: ENSG00000026751

Variants:

dbSNP: 57823
ClinVar: 57823
TCGA: ENSG00000026751
COSMIC: SLAMF7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000026751ENST00000359331Q9NQ25
ENSG00000026751ENST00000368042Q9NQ25
ENSG00000026751ENST00000368043Q9NQ25
ENSG00000026751ENST00000441662Q9NQ25
ENSG00000026751ENST00000444090Q9NQ25
ENSG00000026751ENST00000458104B4DVL7
ENSG00000026751ENST00000458602Q9NQ25
ENSG00000026751ENST00000495334R4GND0
ENSG00000026751ENST00000621377B4DW98

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374200842023Identification and elucidation of cross talk between SLAM Family Member 7 (SLAMF7) and Toll-like receptor (TLR) pathways in monocytes and macrophages.1
377544882023SLAMF7 as a Promising Immunotherapeutic Target in Multiple Myeloma Treatments.2
374200842023Identification and elucidation of cross talk between SLAM Family Member 7 (SLAMF7) and Toll-like receptor (TLR) pathways in monocytes and macrophages.1
377544882023SLAMF7 as a Promising Immunotherapeutic Target in Multiple Myeloma Treatments.2
346935212022SLAMF7 selectively favors degranulation to promote cytotoxicity in human NK cells.5
351481992022SLAMF7 engagement superactivates macrophages in acute and chronic inflammation.22
361990662022SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity.4
346935212022SLAMF7 selectively favors degranulation to promote cytotoxicity in human NK cells.5
351481992022SLAMF7 engagement superactivates macrophages in acute and chronic inflammation.22
361990662022SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity.4
330170792021CD319 (SLAMF7) an alternative marker for detecting plasma cells in the presence of daratumumab or elotuzumab.12
332885452021SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment.35
334202832021Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments.6
347324122021SLAMF7 and TREM1 Mediate Immunogenic Cell Death in Colorectal Cancer Cells: Focus on Microsatellite Stability.4
330170792021CD319 (SLAMF7) an alternative marker for detecting plasma cells in the presence of daratumumab or elotuzumab.12

Citation

Dessen P

SLAMF7 (SLAM family member 7)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55902/slamf7-(slam-family-member-7)