PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase)
2016-08-01 AffiliationIdentity
HGNC
LOCATION
4q12
LOCUSID
ALIAS
ADE2,ADE2H1,AIRC,PAIS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10606
MIM: 172439
HGNC: 8587
Ensembl: ENSG00000128050
Variants:
dbSNP: 10606
ClinVar: 10606
TCGA: ENSG00000128050
COSMIC: PAICS
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37848033 | 2023 | PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly. | 4 |
| 37848033 | 2023 | PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly. | 4 |
| 35285625 | 2022 | Evidence Supporting Substrate Channeling between Domains of Human PAICS: A Time-Course Analysis of (13)C-Bicarbonate Incorporation. | 0 |
| 35331738 | 2022 | Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling. | 3 |
| 35285625 | 2022 | Evidence Supporting Substrate Channeling between Domains of Human PAICS: A Time-Course Analysis of (13)C-Bicarbonate Incorporation. | 0 |
| 35331738 | 2022 | Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling. | 3 |
| 34173716 | 2021 | PAICS is related to glioma grade and can promote glioma growth and migration. | 6 |
| 34323174 | 2021 | Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer. | 2 |
| 34173716 | 2021 | PAICS is related to glioma grade and can promote glioma growth and migration. | 6 |
| 34323174 | 2021 | Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer. | 2 |
| 32571877 | 2020 | Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target. | 7 |
| 32632107 | 2020 | PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2. | 12 |
| 32571877 | 2020 | Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target. | 7 |
| 32632107 | 2020 | PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2. | 12 |
| 30641222 | 2019 | Roles of highly expressed PAICS in lung adenocarcinoma. | 29 |
Citation
Dessen P
PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase)
Atlas Genet Cytogenet Oncol Haematol. 2016-08-01
Online version: http://atlasgeneticsoncology.org/gene/55910/meetings/deep-insight-explorer/
