Identity
HGNC
LOCATION
6p22.3
LOCUSID
ALIAS
BLOC1S8,DBND,HPS7,My031,SDY
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84062
MIM: 607145
HGNC: 17328
Ensembl: ENSG00000047579
Variants:
dbSNP: 84062
ClinVar: 84062
TCGA: ENSG00000047579
COSMIC: DTNBP1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10832 | corticosteroids | Chemical | VariantAnnotation | associated | PD | 30697902 | |
| PA443450 | Asthma | Disease | VariantAnnotation | associated | PD | 30697902 | |
| PA447215 | Psychotic Disorders | Disease | ClinicalAnnotation | associated | PD | 17555717 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 19065121 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 19065121 | |
| PA449061 | clozapine | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449841 | haloperidol | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 27023437 | |
| PA450403 | methamphetamine | Chemical | ClinicalAnnotation | associated | PD | 17555717 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37172778 | 2023 | Hermansky-Pudlak syndrome with early onset inflammatory bowel disease due to loss of dysbindin expression. | 0 |
| 37218669 | 2023 | Dopaminergic signalling and behavioural alterations by Comt-Dtnbp1 genetic interaction and their clinical relevance. | 0 |
| 37480305 | 2023 | SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED FOLLOW UP STUDY. | 0 |
| 37172778 | 2023 | Hermansky-Pudlak syndrome with early onset inflammatory bowel disease due to loss of dysbindin expression. | 0 |
| 37218669 | 2023 | Dopaminergic signalling and behavioural alterations by Comt-Dtnbp1 genetic interaction and their clinical relevance. | 0 |
| 37480305 | 2023 | SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED FOLLOW UP STUDY. | 0 |
| 34997064 | 2022 | Objective to identify and verify the regulatory mechanism of DTNBP1 as a prognostic marker for hepatocellular carcinoma. | 4 |
| 35124166 | 2022 | Protein Kinase B/Akt1 Phosphorylates Dysbindin-1A at Serine 10 to Regulate Neuronal Development. | 4 |
| 34997064 | 2022 | Objective to identify and verify the regulatory mechanism of DTNBP1 as a prognostic marker for hepatocellular carcinoma. | 4 |
| 35124166 | 2022 | Protein Kinase B/Akt1 Phosphorylates Dysbindin-1A at Serine 10 to Regulate Neuronal Development. | 4 |
| 31492942 | 2021 | The epistatic interaction between the dopamine D3 receptor and dysbindin-1 modulates higher-order cognitive functions in mice and humans. | 27 |
| 32394511 | 2021 | Schizophrenia-associated gene dysbindin-1 and tardive dyskinesia. | 2 |
| 33186610 | 2021 | Loss of Dysbindin Implicates Synaptic Vesicle Replenishment Dysregulation as a Potential Pathogenic Mechanism in Schizophrenia. | 4 |
| 33890175 | 2021 | Cortical copper transporter expression in schizophrenia: interactions of risk gene dysbindin-1. | 1 |
| 31492942 | 2021 | The epistatic interaction between the dopamine D3 receptor and dysbindin-1 modulates higher-order cognitive functions in mice and humans. | 27 |
Citation
Dessen P
DTNBP1 (dystrobrevin binding protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/55950/dtnbp1-(dystrobrevin-binding-protein-1)
