PDE1C (phosphodiesterase 1C)

2016-10-01 Affiliation

Identity

HGNC

PDE1C

LOCATION

7p14.3

LOCUSID

5137

ALIAS

DFNA74,Hcam3,cam-PDE

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5137
MIM: 602987
HGNC: 8776
Ensembl: ENSG00000154678

Variants:

dbSNP: 5137
ClinVar: 5137
TCGA: ENSG00000154678
COSMIC: PDE1C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000154678	ENST00000321453	Q14123
ENSG00000154678	ENST00000396182	Q14123
ENSG00000154678	ENST00000396184	Q14123
ENSG00000154678	ENST00000396189	F8W905
ENSG00000154678	ENST00000396191	Q14123
ENSG00000154678	ENST00000396193	A0A0A0MS69

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Calcium signaling pathway	KEGG	ko04020
Olfactory transduction	KEGG	ko04740
Taste transduction	KEGG	ko04742
Purine metabolism	KEGG	hsa00230
Calcium signaling pathway	KEGG	hsa04020
Olfactory transduction	KEGG	hsa04740
Taste transduction	KEGG	hsa04742
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
DAG and IP3 signaling	REACTOME	R-HSA-1489509
CaM pathway	REACTOME	R-HSA-111997
Calmodulin induced events	REACTOME	R-HSA-111933
Cam-PDE 1 activation	REACTOME	R-HSA-111957
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
EGFR interacts with phospholipase C-gamma	REACTOME	R-HSA-212718
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PLC-gamma1 signalling	REACTOME	R-HSA-167021
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by GPCR	REACTOME	R-HSA-372790
Opioid Signalling	REACTOME	R-HSA-111885
G-protein mediated events	REACTOME	R-HSA-112040
PLC beta mediated events	REACTOME	R-HSA-112043
Ca-dependent events	REACTOME	R-HSA-111996

References

Pubmed ID	Year	Title	Citations
33789162	2021	Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes.	1
34312235	2021	Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm.	14
33789162	2021	Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes.	1
34312235	2021	Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm.	14
29860631	2018	A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss.	10
29860631	2018	A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss.	10
25620587	2016	Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro.	17
25620587	2016	Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro.	17
25608528	2015	Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.	54
25608528	2015	Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.	54
20110084	2010	Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.	21
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20110084	2010	Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.	21
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	94

Citation

Dessen P

PDE1C (phosphodiesterase 1C)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55951/pde1c-(phosphodiesterase-1c)

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