Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1621
MIM: 609312
HGNC: 2689
Ensembl: ENSG00000123454
Variants:
dbSNP: 1621
ClinVar: 1621
TCGA: ENSG00000123454
COSMIC: DBH
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000123454 | ENST00000263611 | Q5T382 |
| ENSG00000123454 | ENST00000393056 | P09172 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712362 | Analgesics | Chemical | ClinicalAnnotation | associated | 25096645 | ||
| PA164712462 | Antiinflammatory agents, non-steroids | Chemical | ClinicalAnnotation | associated | 25096645 | ||
| PA164712741 | Ergot alkaloids | Chemical | ClinicalAnnotation | associated | 25096645 | ||
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | ||
| PA445043 | Opioid-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 29210332 | |
| PA445768 | Substance Withdrawal Syndrome | Disease | ClinicalAnnotation | associated | 25096645 | ||
| PA446878 | Cocaine-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 24809448 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 22947179 | |
| PA448687 | bupropion | Chemical | ClinicalAnnotation | associated | PD | 22947179 | |
| PA449376 | disulfiram | Chemical | Pathway | associated | |||
| PA450213 | levodopa | Chemical | ClinicalAnnotation | associated | PD | 24809448 | |
| PA450588 | naltrexone | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451566 | sumatriptan | Chemical | ClinicalAnnotation | associated | 25096645 | ||
| PA452618 | opioids | Chemical | ClinicalAnnotation | associated | PD | 25096645, 29210332 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36120985 | 2024 | Association of dopamine β-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population. | 0 |
| 38761858 | 2024 | Right thalamic volume mediates impact of the dopamine beta-hydroxylase gene on the endowment effect. | 0 |
| 36120985 | 2024 | Association of dopamine β-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population. | 0 |
| 38761858 | 2024 | Right thalamic volume mediates impact of the dopamine beta-hydroxylase gene on the endowment effect. | 0 |
| 37148523 | 2023 | Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (DΒH) Polymorphisms with Susceptibility to Dementia (SADEM Study). | 1 |
| 37493923 | 2023 | Effect of rs1108580 of DBH and rs1006737 of CACNA1C on Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort. | 0 |
| 37148523 | 2023 | Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (DΒH) Polymorphisms with Susceptibility to Dementia (SADEM Study). | 1 |
| 37493923 | 2023 | Effect of rs1108580 of DBH and rs1006737 of CACNA1C on Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort. | 0 |
| 36143905 | 2022 | Association between 19-bp Insertion/Deletion Polymorphism of Dopamine β-Hydroxylase and Autism Spectrum Disorder in Thai Patients. | 0 |
| 36143905 | 2022 | Association between 19-bp Insertion/Deletion Polymorphism of Dopamine β-Hydroxylase and Autism Spectrum Disorder in Thai Patients. | 0 |
| 34743284 | 2021 | Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas. | 9 |
| 34743284 | 2021 | Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas. | 9 |
| 31771069 | 2020 | Relationships of Cerebrospinal Fluid Alzheimer's Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms. | 9 |
| 31913053 | 2020 | Association of regulatory variants of dopamine β-hydroxylase with cognition and tardive dyskinesia in schizophrenia subjects. | 2 |
| 32896003 | 2020 | Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia. | 2 |
Citation
Dessen P
DBH (dopamine beta-hydroxylase)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/55960/dbh-(dopamine-beta-hydroxylase)
