Identity
HGNC
LOCATION
16q21
LOCUSID
ALIAS
DEE82,KAT4,KATIV,KYAT4,mitAAT
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2806
MIM: 138150
HGNC: 4433
Ensembl: ENSG00000125166
Variants:
dbSNP: 2806
ClinVar: 2806
TCGA: ENSG00000125166
COSMIC: GOT2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000125166 | ENST00000245206 | P00505 |
| ENSG00000125166 | ENST00000434819 | P00505 |
| ENSG00000125166 | ENST00000568368 | H3BRE7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38095985 | 2023 | Low expression of GOT2 promotes tumor progress and predicts poor prognosis in hepatocellular carcinoma. | 1 |
| 38153082 | 2023 | Surgical resection of lung cancer inhibits mRNA expression of GOT2 gene encoding kynurenine aminotransferase in leukocytes. | 0 |
| 38095985 | 2023 | Low expression of GOT2 promotes tumor progress and predicts poor prognosis in hepatocellular carcinoma. | 1 |
| 38153082 | 2023 | Surgical resection of lung cancer inhibits mRNA expression of GOT2 gene encoding kynurenine aminotransferase in leukocytes. | 0 |
| 35895805 | 2022 | GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors. | 18 |
| 35895805 | 2022 | GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors. | 18 |
| 34077306 | 2021 | Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer. | 19 |
| 34077306 | 2021 | Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer. | 19 |
| 32499446 | 2020 | High circ-SEC31A expression predicts unfavorable prognoses in non-small cell lung cancer by regulating the miR-520a-5p/GOT-2 axis. | 12 |
| 32499446 | 2020 | High circ-SEC31A expression predicts unfavorable prognoses in non-small cell lung cancer by regulating the miR-520a-5p/GOT-2 axis. | 12 |
| 30714292 | 2019 | Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation. | 23 |
| 30993423 | 2019 | Association between CYP2E1 and GOT2 gene polymorphisms and susceptibility and low-dose N,N-dimethylformamide occupational exposure-induced liver injury. | 1 |
| 31422819 | 2019 | Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy. | 25 |
| 30714292 | 2019 | Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation. | 23 |
| 30993423 | 2019 | Association between CYP2E1 and GOT2 gene polymorphisms and susceptibility and low-dose N,N-dimethylformamide occupational exposure-induced liver injury. | 1 |
Citation
Dessen P
GOT2 (glutamic-oxaloacetic transaminase 2)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/55965/got2-(glutamic-oxaloacetic-transaminase-2)
