Identity
HGNC
LOCATION
10p12.2
LOCUSID
ALIAS
CFAP194,CT141,FAP194,Repro-SA-1,pf16
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9576
MIM: 605730
HGNC: 11215
Ensembl: ENSG00000077327
Variants:
dbSNP: 9576
ClinVar: 9576
TCGA: ENSG00000077327
COSMIC: SPAG6
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38147275 | 2024 | SPAG6 regulates cell proliferation and apoptosis via TGF-β/Smad signal pathway in adult B-cell acute lymphoblastic leukemia. | 1 |
| 38147275 | 2024 | SPAG6 regulates cell proliferation and apoptosis via TGF-β/Smad signal pathway in adult B-cell acute lymphoblastic leukemia. | 1 |
| 35232447 | 2022 | Homozygous SPAG6 variants can induce nonsyndromic asthenoteratozoospermia with severe MMAF. | 10 |
| 35667090 | 2022 | Upregulated SPAG6 promotes acute myeloid leukemia progression through MYO1D that regulates the EGFR family expression. | 5 |
| 35232447 | 2022 | Homozygous SPAG6 variants can induce nonsyndromic asthenoteratozoospermia with severe MMAF. | 10 |
| 35667090 | 2022 | Upregulated SPAG6 promotes acute myeloid leukemia progression through MYO1D that regulates the EGFR family expression. | 5 |
| 34600138 | 2021 | Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia. | 2 |
| 34600138 | 2021 | Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia. | 2 |
| 32124190 | 2020 | Patients with severe asthenoteratospermia carrying SPAG6 or RSPH3 mutations have a positive pregnancy outcome following intracytoplasmic sperm injection. | 15 |
| 33000212 | 2020 | SPAG6 promotes cell proliferation and inhibits apoptosis through the PTEN/PI3K/AKT pathway in Burkitt lymphoma. | 7 |
| 32124190 | 2020 | Patients with severe asthenoteratospermia carrying SPAG6 or RSPH3 mutations have a positive pregnancy outcome following intracytoplasmic sperm injection. | 15 |
| 33000212 | 2020 | SPAG6 promotes cell proliferation and inhibits apoptosis through the PTEN/PI3K/AKT pathway in Burkitt lymphoma. | 7 |
| 30835546 | 2019 | Upregulation of SPAG6 in Myelodysplastic Syndrome: Knockdown Inhibits Cell Proliferation via AKT/FOXO Signaling Pathway. | 14 |
| 30835546 | 2019 | Upregulation of SPAG6 in Myelodysplastic Syndrome: Knockdown Inhibits Cell Proliferation via AKT/FOXO Signaling Pathway. | 14 |
| 29749435 | 2018 | SPAG6 silencing induces apoptosis in the myelodysplastic syndrome cell line SKM‑1 via the PTEN/PI3K/AKT signaling pathway in vitro and in vivo. | 11 |
Citation
Dessen P
SPAG6 (sperm associated antigen 6)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/55971/spag6-(sperm-associated-antigen-6)
