CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2)

2016-10-01  

Identity

HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
MRD10

Other Information

Locus ID:

NCBI: 10369
MIM: 602911
HGNC: 1406
Ensembl: ENSG00000166862

Variants:

dbSNP: 10369
ClinVar: 10369
TCGA: ENSG00000166862
COSMIC: CACNG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166862ENST00000300105Q9Y698

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium ChannelsREACTOMER-HSA-112308
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Muscle contractionREACTOMER-HSA-397014
Developmental BiologyREACTOMER-HSA-1266738
LGI-ADAM interactionsREACTOMER-HSA-5682910
Cardiac conductionREACTOMER-HSA-5576891
Phase 0 - rapid depolarisationREACTOMER-HSA-5576892
Phase 2 - plateau phaseREACTOMER-HSA-5576893

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447199Bipolar DisorderDiseaseClinicalAnnotationassociatedPD18408563, 21047205
PA450243lithiumChemicalClinicalAnnotationassociatedPD18408563, 21047205

References

Pubmed IDYearTitleCitations
374913672023TARPγ2 Is Required for Normal AMPA Receptor Expression and Function in Direction-Selective Circuits of the Mammalian Retina.0
374913672023TARPγ2 Is Required for Normal AMPA Receptor Expression and Function in Direction-Selective Circuits of the Mammalian Retina.0
357760362022Association between CACNG2 polymorphisms (rs4820242, rs2284015 and rs2284017) and chronic peripheral neuropathic pain risk in a Mexican population.0
357760362022Association between CACNG2 polymorphisms (rs4820242, rs2284015 and rs2284017) and chronic peripheral neuropathic pain risk in a Mexican population.0
303715582019CACNG2 polymorphisms associate with chronic pain after mastectomy.12
307382512019Study of 45 candidate genes suggests CACNG2 may be associated with lithium response in bipolar disorder.7
303715582019CACNG2 polymorphisms associate with chronic pain after mastectomy.12
307382512019Study of 45 candidate genes suggests CACNG2 may be associated with lithium response in bipolar disorder.7
287681972017Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.17
287681972017Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.17
267441922016Superactivation of AMPA receptors by auxiliary proteins.25
274181732016Molecular Changes Involving MEK3-p38 MAPK Activation in Chronic Masticatory Myalgia.3
277057822016Stargazin Modulation of AMPA Receptors.34
267441922016Superactivation of AMPA receptors by auxiliary proteins.25
274181732016Molecular Changes Involving MEK3-p38 MAPK Activation in Chronic Masticatory Myalgia.3

Citation

Dessen P

CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55972/cacng2-(calcium-voltage-gated-channel-auxiliary-subunit-gamma-2)