Identity
HGNC
LOCATION
1q42.11
LOCUSID
ALIAS
DEGS,DEGS-1,DES1,Des-1,FADS7,HLD18,MIG15,MLD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8560
MIM: 615843
HGNC: 13709
Ensembl: ENSG00000143753
Variants:
dbSNP: 8560
ClinVar: 8560
TCGA: ENSG00000143753
COSMIC: DEGS1
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38342436 | 2024 | Loss of function and reduced levels of sphingolipid desaturase DEGS1 variants are both relevant in disease mechanism. | 0 |
| 38342436 | 2024 | Loss of function and reduced levels of sphingolipid desaturase DEGS1 variants are both relevant in disease mechanism. | 0 |
| 36951944 | 2023 | Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity. | 6 |
| 37890668 | 2023 | The atypical sphingolipid SPB 18:1(14Z);O2 is a biomarker for DEGS1 related hypomyelinating leukodystrophy. | 0 |
| 36951944 | 2023 | Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity. | 6 |
| 37890668 | 2023 | The atypical sphingolipid SPB 18:1(14Z);O2 is a biomarker for DEGS1 related hypomyelinating leukodystrophy. | 0 |
| 36165222 | 2022 | Dihydroceramide desaturase 1 (DES1) promotes anchorage-independent survival downstream of HER2-driven glucose uptake and metabolism. | 2 |
| 36184516 | 2022 | Dihydroceramide Δ4-Desaturase 1 Is Not Involved in SARS-CoV-2 Infection. | 0 |
| 36165222 | 2022 | Dihydroceramide desaturase 1 (DES1) promotes anchorage-independent survival downstream of HER2-driven glucose uptake and metabolism. | 2 |
| 36184516 | 2022 | Dihydroceramide Δ4-Desaturase 1 Is Not Involved in SARS-CoV-2 Infection. | 0 |
| 33852856 | 2021 | Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress. | 8 |
| 34106748 | 2021 | N-(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide Δ4-Desaturase 1-Independent Mechanism. | 4 |
| 33852856 | 2021 | Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress. | 8 |
| 34106748 | 2021 | N-(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide Δ4-Desaturase 1-Independent Mechanism. | 4 |
| 30620338 | 2019 | DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans. | 39 |
Citation
Dessen P
DEGS1 (delta 4-desaturase, sphingolipid 1)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56005/degs1-(delta-4-desaturase-sphingolipid-1)
