Identity
HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
LY9B,SLAMF5,hCD84,mCD84
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8832
MIM: 604513
HGNC: 1704
Ensembl: ENSG00000066294
Variants:
dbSNP: 8832
ClinVar: 8832
TCGA: ENSG00000066294
COSMIC: CD84
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Hemostasis | REACTOME | R-HSA-109582 |
| Cell surface interactions at the vascular wall | REACTOME | R-HSA-202733 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 27564082 | |
| PA445451 | Psoriasis | Disease | ClinicalAnnotation | associated | PD | 27564082 | |
| PA449515 | etanercept | Chemical | ClinicalAnnotation | associated | PD | 27564082 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33465053 | 2021 | CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma. | 23 |
| 33465053 | 2021 | CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma. | 23 |
| 31772329 | 2020 | Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner. | 2 |
| 31772329 | 2020 | Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner. | 2 |
| 30514120 | 2019 | The temporal pattern of immune and inflammatory proteins prior to a recurrent coronary event in post-acute coronary syndrome patients. | 5 |
| 30514120 | 2019 | The temporal pattern of immune and inflammatory proteins prior to a recurrent coronary event in post-acute coronary syndrome patients. | 5 |
| 29434592 | 2018 | Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8. | 7 |
| 29434592 | 2018 | Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8. | 7 |
| 27452524 | 2017 | CD84 mediates CLL-microenvironment interactions. | 13 |
| 27452524 | 2017 | CD84 mediates CLL-microenvironment interactions. | 13 |
| 23435417 | 2014 | CD84 is a survival receptor for CLL cells. | 16 |
| 24635044 | 2014 | CD84 is markedly up-regulated in Kawasaki disease arteriopathy. | 4 |
| 23435417 | 2014 | CD84 is a survival receptor for CLL cells. | 16 |
| 24635044 | 2014 | CD84 is markedly up-regulated in Kawasaki disease arteriopathy. | 4 |
| 23555300 | 2013 | Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. | 78 |
Citation
Dessen P
CD84 (CD84 molecule)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56016/cd84-(cd84-molecule)
