SELENON (selenoprotein N)

2016-10-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
CFTD,MDRS1,RSMD1,RSS,SELN,SEPN1

Other Information

Locus ID:

NCBI: 57190
MIM: 606210
HGNC: 15999
Ensembl: ENSG00000162430

Variants:

dbSNP: 57190
ClinVar: 57190
TCGA: ENSG00000162430
COSMIC: SELENON

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162430ENST00000354177H9KV50
ENSG00000162430ENST00000361547Q9NZV5
ENSG00000162430ENST00000374315Q9NZV5
ENSG00000162430ENST00000630065A0A0D9SGI9

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
326612882021Defective endoplasmic reticulum-mitochondria contacts and bioenergetics in SEPN1-related myopathy.21
337624972021[Selenoprotein-related myopathy in a patient with old-age-onset type 2 respiratory failure: a case report].1
326612882021Defective endoplasmic reticulum-mitochondria contacts and bioenergetics in SEPN1-related myopathy.21
337624972021[Selenoprotein-related myopathy in a patient with old-age-onset type 2 respiratory failure: a case report].1
327961312020The clinical, histologic, and genotypic spectrum of SEPN1-related myopathy: A case series.23
328175442020Selenoprotein N is an endoplasmic reticulum calcium sensor that links luminal calcium levels to a redox activity.30
328648022020The first report of two homozygous sequence variants in FKRP and SELENON genes associated with syndromic congenital muscular dystrophy in Iran: Further expansion of the clinical phenotypes.1
330378642020Selenoprotein N-related myopathy: a retrospective natural history study to guide clinical trials.10
327961312020The clinical, histologic, and genotypic spectrum of SEPN1-related myopathy: A case series.23
328175442020Selenoprotein N is an endoplasmic reticulum calcium sensor that links luminal calcium levels to a redox activity.30
328648022020The first report of two homozygous sequence variants in FKRP and SELENON genes associated with syndromic congenital muscular dystrophy in Iran: Further expansion of the clinical phenotypes.1
330378642020Selenoprotein N-related myopathy: a retrospective natural history study to guide clinical trials.10
318802142019High glucose and TGF-β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells.6
318802142019High glucose and TGF-β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells.6
267807522016SEPN1-related myopathy in three patients: novel mutations and diagnostic clues.7

Citation

Dessen P

SELENON (selenoprotein N)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56019/