Identity
HGNC
LOCATION
11q13.3
LOCUSID
ALIAS
SHEP10,TPC2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 219931
MIM: 612163
HGNC: 20820
Ensembl: ENSG00000162341
Variants:
dbSNP: 219931
ClinVar: 219931
TCGA: ENSG00000162341
COSMIC: TPCN2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33465068 | 2021 | Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect. | 9 |
| 33875769 | 2021 | Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2. | 20 |
| 33465068 | 2021 | Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect. | 9 |
| 33875769 | 2021 | Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2. | 20 |
| 30860481 | 2019 | Structural mechanisms of phospholipid activation of the human TPC2 channel. | 53 |
| 30860481 | 2019 | Structural mechanisms of phospholipid activation of the human TPC2 channel. | 53 |
| 29563152 | 2018 | Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca(2+) Mobilization From Acidic Stores in Pancreatic α-Cells. | 43 |
| 29705952 | 2018 | Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2. | 20 |
| 29990474 | 2018 | TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells. | 21 |
| 29563152 | 2018 | Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca(2+) Mobilization From Acidic Stores in Pancreatic α-Cells. | 43 |
| 29705952 | 2018 | Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2. | 20 |
| 29990474 | 2018 | TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells. | 21 |
| 28096396 | 2017 | Tuning the ion selectivity of two-pore channels. | 57 |
| 28923947 | 2017 | TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms. | 33 |
| 28096396 | 2017 | Tuning the ion selectivity of two-pore channels. | 57 |
Citation
Dessen P
TPCN2 (two pore segment channel 2)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56050/tpcn2-(two-pore-segment-channel-2)
