VPS33B (VPS33B late endosome and lysosome associated)

2016-10-01  

Identity

HGNC
LOCATION
15q26.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 26276
MIM: 608552
HGNC: 12712
Ensembl: ENSG00000184056

Variants:

dbSNP: 26276
ClinVar: 26276
TCGA: ENSG00000184056
COSMIC: VPS33B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184056ENST00000333371Q9H267
ENSG00000184056ENST00000333371A0A0S2Z577
ENSG00000184056ENST00000535906F5H008
ENSG00000184056ENST00000574755G3V3F9

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370624172023The Sec1-Munc18 protein VPS33B forms a uniquely bidirectional complex with VPS16B.2
370624172023The Sec1-Munc18 protein VPS33B forms a uniquely bidirectional complex with VPS16B.2
349056162022Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet α-granules.6
362327262022Mucopolysaccharidosis-Plus Syndrome: Report on a Polish Patient with a Novel VPS33A Variant with Comparison with Other Described Patients.2
349056162022Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet α-granules.6
362327262022Mucopolysaccharidosis-Plus Syndrome: Report on a Polish Patient with a Novel VPS33A Variant with Comparison with Other Described Patients.2
337883462021VPS33B interacts with NESG1 to suppress cell growth and cisplatin chemoresistance in ovarian cancer.3
337883462021VPS33B interacts with NESG1 to suppress cell growth and cisplatin chemoresistance in ovarian cancer.3
311251232020VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer.17
311251232020VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer.17
309443082019VPS33B interacts with NESG1 to modulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma.41
314791772019Novel missense mutation in VPS33B is associated with isolated low gamma-glutamyltransferase cholestasis: Attenuated, incomplete phenotype of arthrogryposis, renal dysfunction, and cholestasis syndrome.10
315011562019Mechanism of platelet α-granule biogenesis: study of cargo transport and the VPS33B-VPS16B complex in a model system.7
309443082019VPS33B interacts with NESG1 to modulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma.41
314791772019Novel missense mutation in VPS33B is associated with isolated low gamma-glutamyltransferase cholestasis: Attenuated, incomplete phenotype of arthrogryposis, renal dysfunction, and cholestasis syndrome.10

Citation

Dessen P

VPS33B (VPS33B late endosome and lysosome associated)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56053/vps33b-(vps33b-late-endosome-and-lysosome-associated)