Identity
HGNC
LOCATION
8q22.1
LOCUSID
ALIAS
EAPF,PHAFIN2,ZFYVE18
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79666
MIM: 615208
HGNC: 20757
Ensembl: ENSG00000175895
Variants:
dbSNP: 79666
ClinVar: 79666
TCGA: ENSG00000175895
COSMIC: PLEKHF2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000175895 | ENST00000315367 | Q9H8W4 |
| ENSG00000175895 | ENST00000519516 | Q9H8W4 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34772942 | 2021 | The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. | 11 |
| 34772942 | 2021 | The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. | 11 |
| 32126233 | 2020 | The C-terminal acidic motif of Phafin2 inhibits PH domain binding to phosphatidylinositol 3-phosphate. | 6 |
| 32619574 | 2020 | Bioinformatics analysis of the genes involved in the extension of prostate cancer to adjacent lymph nodes by supervised and unsupervised machine learning methods: The role of SPAG1 and PLEKHF2. | 11 |
| 32126233 | 2020 | The C-terminal acidic motif of Phafin2 inhibits PH domain binding to phosphatidylinositol 3-phosphate. | 6 |
| 32619574 | 2020 | Bioinformatics analysis of the genes involved in the extension of prostate cancer to adjacent lymph nodes by supervised and unsupervised machine learning methods: The role of SPAG1 and PLEKHF2. | 11 |
| 28152563 | 2017 | Structural, thermodynamic, and phosphatidylinositol 3-phosphate binding properties of Phafin2. | 6 |
| 28152563 | 2017 | Structural, thermodynamic, and phosphatidylinositol 3-phosphate binding properties of Phafin2. | 6 |
| 24416124 | 2014 | Lysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagy. | 28 |
| 24416124 | 2014 | Lysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagy. | 28 |
| 22816767 | 2012 | The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion. | 16 |
| 22816767 | 2012 | The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion. | 16 |
| 19995552 | 2010 | Phafin2 modulates the structure and function of endosomes by a Rab5-dependent mechanism. | 8 |
| 19995552 | 2010 | Phafin2 modulates the structure and function of endosomes by a Rab5-dependent mechanism. | 8 |
| 18288467 | 2008 | EAPF/Phafin-2, a novel endoplasmic reticulum-associated protein, facilitates TNF-alpha-triggered cellular apoptosis through endoplasmic reticulum-mitochondrial apoptotic pathway. | 10 |
Citation
Dessen P
PLEKHF2 (pleckstrin homology and FYVE domain containing 2)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56065/plekhf2-(pleckstrin-homology-and-fyve-domain-containing-2)
