DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor)

2016-10-01

Identity

HGNC

DIMT1

LOCATION

5q12.1

LOCUSID

27292

ALIAS

DIM1,DIMT1L,HSA9761,HUSSY5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27292
MIM: 612499
HGNC: 30217
Ensembl: ENSG00000086189

Variants:

dbSNP: 27292
ClinVar: 27292
TCGA: ENSG00000086189
COSMIC: DIMT1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000086189	ENST00000199320	Q9UNQ2
ENSG00000086189	ENST00000506390	A0A0C4DGB1
ENSG00000086189	ENST00000514911	D6RCL3
ENSG00000086189	ENST00000651114	A0A494C0G7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
rRNA modification in the nucleus and cytosol	REACTOME	R-HSA-6790901
rRNA processing	REACTOME	R-HSA-72312
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
25187177	2014	Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection.	53
25851604	2015	The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.	81
25851604	2015	The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.	81
28164410	2017	Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myeloma.	22
28164410	2017	Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myeloma.	22
28601661	2017	DIMT1 overexpression correlates with progression and prognosis in gastric carcinoma.	5
28601661	2017	DIMT1 overexpression correlates with progression and prognosis in gastric carcinoma.	5
32616653	2020	Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation.	13
32616653	2020	Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation.	13
34473991	2021	Human DIMT1 generates N(2)(6,6)A-dimethylation-containing small RNAs.	3

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Citation

Dessen P

DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56066