Identity
HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
MUNC18-3,MUNC18C,PSP,UNC-18C
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6814
MIM: 608339
HGNC: 11446
Ensembl: ENSG00000116266
Variants:
dbSNP: 6814
ClinVar: 6814
TCGA: ENSG00000116266
COSMIC: STXBP3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000116266 | ENST00000370008 | O00186 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33891011 | 2021 | Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. | 6 |
| 33891011 | 2021 | Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. | 6 |
| 29284677 | 2018 | Depletion of the membrane-fusion regulator Munc18c attenuates caerulein hyperstimulation-induced pancreatitis. | 8 |
| 29284677 | 2018 | Depletion of the membrane-fusion regulator Munc18c attenuates caerulein hyperstimulation-induced pancreatitis. | 8 |
| 28294518 | 2017 | Disruption of protein complexes containing protein phosphatase 2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells. | 2 |
| 28798239 | 2017 | Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells. | 9 |
| 28294518 | 2017 | Disruption of protein complexes containing protein phosphatase 2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells. | 2 |
| 28798239 | 2017 | Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells. | 9 |
| 25190515 | 2014 | Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cells. | 13 |
| 25190515 | 2014 | Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cells. | 13 |
| 23700440 | 2013 | Munc18c in adipose tissue is downregulated in obesity and is associated with insulin. | 9 |
| 23700440 | 2013 | Munc18c in adipose tissue is downregulated in obesity and is associated with insulin. | 9 |
| 22390153 | 2012 | Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS). | 4 |
| 22390153 | 2012 | Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS). | 4 |
| 21444687 | 2011 | Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis. | 45 |
Citation
Dessen P
STXBP3 (syntaxin binding protein 3)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56092/stxbp3-(syntaxin-binding-protein-3)
