OAZ2 (ornithine decarboxylase antizyme 2)

2016-10-01  

Identity

HGNC
OAZ2
LOCATION
15q22.31
LOCUSID
4947
ALIAS
AZ2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4947
MIM: 604152
HGNC: 8096
Ensembl: ENSG00000180304

Variants:

dbSNP: 4947
ClinVar: 4947
TCGA: ENSG00000180304
COSMIC: OAZ2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180304ENST00000326005O95190
ENSG00000180304ENST00000559753J3QLV9
ENSG00000180304ENST00000559912J3KRW5
ENSG00000180304ENST00000560258J3KS80

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Regulation of ornithine decarboxylase (ODC)REACTOMER-HSA-350562

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
301751542018miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells.16
301751542018miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells.16
232601692013Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.17
232601692013Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.17
220082212012Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.24
220082212012Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.24
199604352010The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.29
199604352010The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.29
97820761998A second mammalian antizyme: conservation of programmed ribosomal frameshifting.45
97820761998A second mammalian antizyme: conservation of programmed ribosomal frameshifting.45

Citation

Dessen P

OAZ2 (ornithine decarboxylase antizyme 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56100/submit-meetings/teaching-explorer/