Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 53373
MIM: 609666
HGNC: 18182
Ensembl: ENSG00000186815
Variants:
dbSNP: 53373
ClinVar: 53373
TCGA: ENSG00000186815
COSMIC: TPCN1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transmembrane transport of small molecules | REACTOME | R-HSA-382551 |
| Ion channel transport | REACTOME | R-HSA-983712 |
| Stimuli-sensing channels | REACTOME | R-HSA-2672351 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30860481 | 2019 | Structural mechanisms of phospholipid activation of the human TPC2 channel. | 53 |
| 31557916 | 2019 | The Role of Two-Pore Channels in Norepinephrine-Induced [Ca(2+)](i) Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction. | 6 |
| 30860481 | 2019 | Structural mechanisms of phospholipid activation of the human TPC2 channel. | 53 |
| 31557916 | 2019 | The Role of Two-Pore Channels in Norepinephrine-Induced [Ca(2+)](i) Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction. | 6 |
| 28252105 | 2017 | The human two-pore channel 1 is modulated by cytosolic and luminal calcium. | 21 |
| 29129203 | 2017 | NAADP-evoked Ca(2+) signals through two-pore channel-1 require arginine residues in the first S4-S5 linker. | 12 |
| 28252105 | 2017 | The human two-pore channel 1 is modulated by cytosolic and luminal calcium. | 21 |
| 29129203 | 2017 | NAADP-evoked Ca(2+) signals through two-pore channel-1 require arginine residues in the first S4-S5 linker. | 12 |
| 27353380 | 2016 | Differential effects of two-pore channel protein 1 and 2 silencing in MDA-MB-468 breast cancer cells. | 13 |
| 27353380 | 2016 | Differential effects of two-pore channel protein 1 and 2 silencing in MDA-MB-468 breast cancer cells. | 13 |
| 25451935 | 2015 | Organelle-specific subunit interactions of the vertebrate two-pore channel family. | 10 |
| 25665131 | 2015 | Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis. | 8 |
| 25722412 | 2015 | Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. | 270 |
| 26152696 | 2015 | Function and dysfunction of two-pore channels. | 86 |
| 25451935 | 2015 | Organelle-specific subunit interactions of the vertebrate two-pore channel family. | 10 |
Citation
Dessen P
TPCN1 (two pore segment channel 1)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56106/tpcn1-(two-pore-segment-channel-1)
