SYTL4 (synaptotagmin like 4)

2016-10-01  

Identity

HGNC
LOCATION
Xq22.1
LOCUSID
ALIAS
SLP4
FUSION GENES

Other Information

Locus ID:

NCBI: 94121
MIM: 300723
HGNC: 15588
Ensembl: ENSG00000102362

Variants:

dbSNP: 94121
ClinVar: 94121
TCGA: ENSG00000102362
COSMIC: SYTL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102362ENST00000263033Q96C24
ENSG00000102362ENST00000263033A0A024RCF8
ENSG00000102362ENST00000276141Q96C24
ENSG00000102362ENST00000276141A0A024RCF8
ENSG00000102362ENST00000372981Q96C24
ENSG00000102362ENST00000372989Q96C24
ENSG00000102362ENST00000372989A0A024RCF8

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
332773602021Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin.8
332773602021Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin.8
319305962020Epstein-Barr virus-encoded latent membrane protein 1 promotes extracellular vesicle secretion through syndecan-2 and synaptotagmin-like-4 in nasopharyngeal carcinoma cells.19
330422632020SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer.17
319305962020Epstein-Barr virus-encoded latent membrane protein 1 promotes extracellular vesicle secretion through syndecan-2 and synaptotagmin-like-4 in nasopharyngeal carcinoma cells.19
330422632020SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer.17
289060462017The unique N-terminal zinc finger of synaptotagmin-like protein 4 reveals FYVE structure.4
289060462017The unique N-terminal zinc finger of synaptotagmin-like protein 4 reveals FYVE structure.4
270326722016Granuphilin exclusively mediates functional granule docking to the plasma membrane.10
270326722016Granuphilin exclusively mediates functional granule docking to the plasma membrane.10
255952932015Insights into the molecular recognition of the granuphilin C2A domain with PI(4,5)P2.14
265539292015Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.60
255952932015Insights into the molecular recognition of the granuphilin C2A domain with PI(4,5)P2.14
265539292015Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.60
241846452014The C2 domains of granuphilin are high-affinity sensors for plasma membrane lipids.13

Citation

Dessen P

SYTL4 (synaptotagmin like 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56113/sytl4-(synaptotagmin-like-4)