GAREM1 (GRB2 associated regulator of MAPK1 subtype 1)

2016-10-01  

Identity

HGNC
LOCATION
18q12.1
LOCUSID
ALIAS
C18orf11,FAM59A,GAREM,Gm944

Other Information

Locus ID:

NCBI: 64762
MIM: 617998
HGNC: 26136
Ensembl: ENSG00000141441

Variants:

dbSNP: 64762
ClinVar: 64762
TCGA: ENSG00000141441
COSMIC: GAREM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141441ENST00000269209Q9H706
ENSG00000141441ENST00000399218Q9H706
ENSG00000141441ENST00000583696J3QRF3

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
360845562022GAREM1 is involved in controlling body mass in mice and humans.2
360845562022GAREM1 is involved in controlling body mass in mice and humans.2
292737312018GAREM1 regulates the PR interval on electrocardiograms.0
301773872018MicroRNA-128 contributes to the progression of gastric carcinoma through GAREM-mediated MAPK signaling activation.7
292737312018GAREM1 regulates the PR interval on electrocardiograms.0
301773872018MicroRNA-128 contributes to the progression of gastric carcinoma through GAREM-mediated MAPK signaling activation.7
261642322015Functional relationship between CABIT, SAM and 14-3-3 binding domains of GAREM1 that play a role in its subcellular localization.4
261642322015Functional relationship between CABIT, SAM and 14-3-3 binding domains of GAREM1 that play a role in its subcellular localization.4
240032232013A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling.14
240032232013A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling.14
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.94
195092912009GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.23
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.94

Citation

Dessen P

GAREM1 (GRB2 associated regulator of MAPK1 subtype 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56129/deep-insight-explorer/