IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker))

2016-10-01  

Identity

HGNC
LOCATION
14q32.33
LOCUSID
ALIAS
IgG3
FUSION GENES

Other Information

Locus ID:

NCBI: 3502
MIM: 147120
HGNC: 5527
Ensembl: ENSG00000211897
IMGT/GENE-DB:

Variants:

dbSNP: 3502
ClinVar: 3502
TCGA: ENSG00000211897
COSMIC: IGHG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000211897ENST00000390551A0A4W9A917
ENSG00000211897ENST00000641136A0A286YES1

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Creation of C4 and C2 activatorsREACTOMER-HSA-166786
Classical antibody-mediated complement activationREACTOMER-HSA-173623
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485

References

Pubmed IDYearTitleCitations
335730682021Salivary Immunoglobulin Gamma-3 Chain C Is a Promising Noninvasive Biomarker for Systemic Lupus Erythematosus.3
338133922021Serum Proteomic Profiling Reveals Differentially Expressed IGHG3 and A1AG1 as Potential Predictors of Chemotherapeutic Response in Advanced Non-small Cell Lung Cancer.3
335730682021Salivary Immunoglobulin Gamma-3 Chain C Is a Promising Noninvasive Biomarker for Systemic Lupus Erythematosus.3
338133922021Serum Proteomic Profiling Reveals Differentially Expressed IGHG3 and A1AG1 as Potential Predictors of Chemotherapeutic Response in Advanced Non-small Cell Lung Cancer.3
326233422020Chromosome 6p SNP microhaplotypes and IgG3 levels in hemochromatosis probands with HFE p.C282Y homozygosity.3
326233422020Chromosome 6p SNP microhaplotypes and IgG3 levels in hemochromatosis probands with HFE p.C282Y homozygosity.3
299453072018Demonstration of IgG Subclass (IgG1 and IgG3) in Immuno-Related Hemocytopenia.1
301046332018IgG3 regulates tissue-like memory B cells in HIV-infected individuals.19
301162492018The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts.10
299453072018Demonstration of IgG Subclass (IgG1 and IgG3) in Immuno-Related Hemocytopenia.1
301046332018IgG3 regulates tissue-like memory B cells in HIV-infected individuals.19
301162492018The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts.10
262323282015Insights into the effector functions of human IgG3 in the context of an antibody targeting transferrin receptor 1.10
262323282015Insights into the effector functions of human IgG3 in the context of an antibody targeting transferrin receptor 1.10
246193122014Haemoglobin levels in autoimmune haemolytic anaemias at diagnosis: relationship with immunoproteins on red blood cells.2

Citation

Dessen P

IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker))

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56144/ighg3-(immunoglobulin-heavy-constant-gamma-3-(g3m-marker))